用图模型分析病历诊断序列,提前预测炎症性肠病风险。
GraD-IBD: Graph Representation Learning from Diagnosis Trajectories for Early Detection of Inflammatory Bowel Disease

- 将就诊记录转为带时间方向的图结构,捕捉疾病发展轨迹。
- 在真实数据上检测准确率优于现有方法,计算量大幅降低。
- 适合医疗风险预测与电子病历分析的研究者使用。
国际疾病分类(ICD)是全球通用的诊断编码系统,记录每次就诊的诊断事件,为临床任务提供标准化数据基础。然而,ICD编码序列具有不规则性和层级性,给基于N-D网格的序列建模方法带来挑战,导致模型设计过于复杂。本文提出GraD-IBD,一种图诊断模型,将纵向ICD轨迹重构为按就诊分桶、具时间方向的图结构,用于早期检测炎症性肠病(IBD)。我们设计了一种新颖的上下文感知、时间衰减的消息传递机制,有效捕捉时间依赖关系的同时降低模型复杂度。在真实临床数据集上的实验表明,GraD-IBD在IBD检测上持续且稳健地优于当前最优方法,并显著降低计算复杂度。这些结果凸显了图表示学习在从纵向ICD诊断码中实现高效、可扩展、精准疾病风险预测方面的潜力。
原文摘要 · Abstract (English)
International Classification of Diseases (ICD) is a globally recognized coding system that records diagnostic events during each patient encounter, providing a standardized data foundation for various clinical tasks. However, the irregular and hierarchical nature of ICD code sequences poses challenges for N-D lattice-based sequential modeling methods, leading to overly complex model designs. In this paper, we propose GraD-IBD, a graph diagnosis model that reformulates longitudinal ICD trajectories as visit-bucketized, temporally directed graphs to detect the risk of inflammatory bowel disease (IBD). A novel context-aware, time-decay message passing mechanism was developed to capture temporal dependencies while reducing model complexity. The experimental results using a real-world clinical dataset demonstrated consistent and robust improvements in IBD detection over state-of-the-art methods, with significant reductions in computational complexity compared to sequential models. These findings highlight the potential of graph representation learning to enable efficient, scalable, and accurate disease risk prediction from longitudinal ICD diagnosis codes.
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