arXiv:2605.28977cs.LGcs.AI2026-05

对比五种解释方法,揭示脑电抑郁模型的决策热点。

Comparing Post-Hoc Explainable AI Methods for Interpreting Black-Box EEG Models in Depression Detection

论文配图:Comparing Post-Hoc Explainable AI Methods for Interpreting Black-Box EEG Models in Depression Detection
图 1 · 摘自论文原文
  • 用五类后验解释法分析脑电深度模型的决策依据。
  • 前后额叶及右半球是关键区域,不同方法结果部分重合。
  • 方法差异大,需谨慎解读其临床意义。

深度学习已显著提升基于脑电图(EEG)检测重度抑郁症(MDD)的准确率,但高容量模型的决策过程难以解释。本研究在InceptionTime架构上评估了五种后验可解释性方法:基于Shapley值的DeepSHAP、基于梯度的Integrated Gradients、GradCAM、基于扰动的Occlusion与特征重要性排列(Permutation Feature Importance)。在受试者分层的5折交叉验证框架下,对多段脑电数据与受试者进行全局归因聚合分析。结果显示,各方法呈现部分一致的注意力模式,尤其集中在额叶、颞叶和后部区域,尤以右侧为甚。定量比较显示,梯度与扰动方法间一致性较高,而DeepSHAP的归因分布明显不同。方法间的差异凸显了不同假设对解释结果的影响。尽管结果与既往研究中MDD的脑电特征大致吻合,但分析仍具探索性,不能作为确凿的神经生理标志物或临床工具。研究强调了后验可解释性在精神疾病应用中的价值与局限。

原文摘要 · Abstract (English)

Recent advances in deep learning have enabled increasingly accurate electroencephalography (EEG)-based classification of Major Depressive Disorder (MDD), but the decision-making processes of high-capacity models remain difficult to interpret. This study investigates multiple post-hoc explainability methods applied to an InceptionTime architecture trained for EEG-based MDD detection. The analysis includes Shapley-based, gradient-based, and perturbation-based attribution approaches: DeepSHAP, Integrated Gradients, GradCAM, Occlusion, and Permutation Feature Importance. Explainability analysis was performed within a subject-level stratified 5-fold cross-validation framework using global attribution aggregation across EEG segments and subjects. The evaluated methods revealed partially convergent attribution patterns, with recurring emphasis on frontal, temporal, and posterior EEG regions, particularly in the right hemisphere. Quantitative comparison demonstrated substantial agreement between gradient- and perturbation-based approaches, while DeepSHAP produced comparatively distinct attribution distributions. At the same time, variability between explainability methods highlighted the influence of methodological assumptions on the resulting explanations. Overall, the results suggest that different post-hoc explainability approaches capture partially overlapping relevance structures in EEG-based deep learning models for depression detection. Although the observed attribution patterns are broadly consistent with several previous EEG studies of MDD, the analysis should be interpreted as exploratory rather than evidence of definitive neurophysiological biomarkers or clinical applicability. The study highlights both the usefulness and limitations of post-hoc explainability for interpreting black-box EEG classifiers in psychiatric applications.

脑电图可解释AI抑郁症检测

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