自动分割心脏周围脂肪,准确率超98%,助力心血管疾病风险评估。
Towards the automated segmentation of epicardial and mediastinal fats: A multi-manufacturer approach using intersubject registration and random forest
- 基于图像配准与随机森林的全自动分割方法
- 心外膜和纵隔脂肪平均准确率达98.4%,Dice系数96.8%
- 适合临床辅助诊断系统,兼容多厂家CT设备
心脏周围脂肪量与颈动脉硬化、冠状动脉钙化、心房颤动、动脉粥样硬化及癌症发病率等多种健康风险因素相关。由于心肌脂肪分布独立于全身脂肪,其定量分析具有重要意义。本文提出一种全自动方法,用于在标准冠脉钙化扫描CT图像上分割心外膜脂肪和纵隔脂肪。该方法通过图像间个体配准实现粗略对齐,提取像素及其邻域特征,并利用数据挖掘分类算法判断像素类别。实验表明,心外膜脂肪和纵隔脂肪的平均准确率为98.4%,平均真阳性率96.2%,平均Dice相似性指数达96.8%。方法强调最小人为干预与可重复性,适用于临床决策支持系统。
原文摘要 · Abstract (English)
The amount of fat on the surroundings of the heart is correlated to several health risk factors such as carotid stiffness, coronary artery calcification, atrial fibrillation, atherosclerosis, cancer incidence and others. Furthermore, the cardiac fat varies unrelated to the overall fat of the subject, and, therefore, it reinforces the quantitative analysis of these adipose tissues as being essential. Clinical decision support systems are computer programs capable of evaluating information and providing a corresponding diagnosis or data to complement the physicists' analyses. The aim of this work is to propose a method capable of fully automatically segmenting two types of cardiac adipose tissues that stand apart from each other by the pericardium on CT images obtained by the standard acquisition protocol used for coronary calcium scoring. Much effort was devoted to promote minimal user intervention and ease of reproducibility. The methodology proposed in this work consists of a registration, which will roughly adjust input images to a standard, an extraction of features related to pixels and their surrounding area and a segmentation step based on data mining classification algorithms that define if an incoming pixel is of a certain type. Experimentations showed that the achieved mean accuracy for the epicardial and mediastinal fats was 98.4% with a mean true positive rate of 96.2%. In average, the Dice similarity index was equal to 96.8%.
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