arXiv:2605.30865cs.LG2026-05被引 2

GlucoFM通过双流结构分离血糖长期趋势与短期波动,提升代谢表型预测精度。

GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring

论文配图:GlucoFM: A Dual-Stream Foundation Model for Continuous Glucose Monitoring
图 1 · 摘自论文原文
  • 将不规则血糖数据对齐到24小时时间网格,分拆为长期趋势与短期波动双流建模。
  • 在7个表型分类任务中平均提升PR-AUC 4.1点,糖尿病风险预测表现最优。
  • 适用于代谢表型分析与餐后血糖响应预测,适合医疗健康领域研究者使用。

连续血糖监测(CGM)提供了日常代谢生理的密集视图,但现有通用时间序列和专用CGM基础模型通常将血糖轨迹编码为纠缠的单一流序列,仅隐式建模多尺度时间结构。我们提出GlucoFM,一种轻量级CGM基础模型,将不规则记录对齐至24小时时间网格,保留观测掩码,并将血糖动态分解为缓慢变化的糖代谢趋势流与短期偏离流。GlucoFM在来自477名受试者的109,066小时未标注CGM数据上预训练,采用融合日表示的掩码上下文潜在预测与双流时间动态预测。冻结前融合探针证实不同时间侧重:状态令牌优先保留每小时血糖水平,事件令牌更优保留短期变化。在四个不同队列和七个表型分类任务中,GlucoFM在主题无关线性探查中表现最佳,相比最优的专用基础模型平均提升PR-AUC 4.1点,同时支持强跨数据集迁移与少样本适应。其增益在核心代谢结果上最为显著,在所有糖尿病风险与β细胞功能障碍任务中取得最高PR-AUC,且在4个胰岛素抵抗任务中有3项领先。除表型分类外,结合最新CGM、进餐营养与个体背景信息时,相同冻结编码器在轨迹、增量曲线下面积、峰值上升和峰值时间等指标上误差最低。这些结果表明,GlucoFM学习到了可复用的冻结CGM表示,覆盖代谢表型分析与上下文条件下的血糖响应预测。

原文摘要 · Abstract (English)

Continuous glucose monitoring (CGM) provides a dense view of daily metabolic physiology, yet existing generic time-series and CGM-specific foundation models often encode glucose traces as entangled single-stream sequences, leaving their multiscale temporal structure only implicitly modeled. We present GlucoFM, a lightweight CGM foundation model that aligns irregular recordings to a 24-hour chronological grid, preserves observation masks, and decomposes glucose dynamics into slow-varying glycemic trend and short-term deviation streams. GlucoFM is pretrained on 109,066 hours of unlabeled CGM recordings from 477 subjects with masked contextual latent prediction over fused daily representations and temporal dynamics prediction over the two streams. Frozen pre-fusion probes confirm distinct temporal emphasis: state tokens preferentially preserve hourly glucose level, whereas event tokens better retain short-term change. Across four diverse cohorts and seven phenotype-classification tasks, GlucoFM achieves the strongest subject-disjoint linear-probing performance among evaluated baselines, improving average PR-AUC by 4.1 points over the best CGM-specific foundation model, while also supporting strong cross-dataset transfer and few-shot adaptation. Its gains are most pronounced on core metabolic outcomes, leading PR-AUC on all diabetes-risk and $β$-cell dysfunction tasks and on 3 of 4 insulin-resistance tasks. Beyond phenotyping, when combined with recent CGM, meal nutrition, and subject context, the same frozen encoder achieves the lowest two-hour postprandial glycemic response errors among evaluated methods for trajectory, incremental area under the curve, peak rise, and peak timing. Together, these results demonstrate that GlucoFM learns reusable frozen CGM representations spanning metabolic phenotyping and context-conditioned glucose-response prediction.

血糖监测基础模型代谢预测

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