用无造影的 cine MRI 重建个性化心梗3D几何,支持心脏数字孪生模拟。
Personalized 3D Myocardial Infarct Geometry Reconstruction from Cine MRI for Cardiac Digital Twins

- 构建4D心室网格,分离并融合几何与运动特征以定位心梗区。
- 在225例数据上实现0.678±0.011的平均Dice分数,接近LGE金标准。
- 适合需避免造影剂的心脏病患者,助力无创心脏数字孪生建模。
准确的3D心肌梗死(MI)几何表征对构建心脏数字孪生(CDT)以精确模拟电生理过程至关重要。延迟增强磁共振(LGE MRI)虽为临床金标准,但依赖造影剂,限制了肾功能不全患者的使用及长期随访。相比之下,无造影的电影MRI可显示异常心室壁运动,高度提示梗死区域。本研究提出一种显式几何-运动嵌入模型,可全自动从多视角电影MRI中重建个性化、可直接用于仿真的3D心梗几何。具体地,构建4D(3D + t)双心室网格,显式提取并解耦几何感知与运动感知特征;设计双分支模块实现自适应几何-运动融合,捕捉时空依赖关系以映射梗死区域;引入多尺度监督,结合AHA-17分区引导的交叉注意力机制,确保重建结果符合生物物理特性。在225例电影MRI上的实验表明,所提方法在3D心梗重建上表现优异,平均Dice得分为0.678±0.011。下游体外电生理仿真评估结果显示,其结果与LGE-derived真值高度一致,凸显该模型在无造影瘢痕表征与无缝集成至CDT建模中的巨大潜力。代码将在论文接受后公开。
原文摘要 · Abstract (English)
Accurate 3D geometric characterization of myocardial infarction (MI) is essential for building cardiac digital twins (CDTs) to precisely simulate infarct-related electrophysiology. Late gadolinium enhancement magnetic resonance imaging (LGE MRI) is the clinical reference for locating MI, yet its reliance on contrast agents restricts use in renally impaired patients and limits longitudinal follow-ups. As an alternative, contrast-free cine MRI visualizes abnormal ventricular wall motion, which is highly indicative of the infarcted area. In this study, we propose a novel explicit geometry-motion embedded model to fully automatically reconstruct personalized, simulation-ready 3D MI geometries directly from multi-view cine MRIs. Specifically, we construct a 4D (3D + t) biventricular mesh to explicitly extract and decouple geometry-aware and motion-aware features. We further design a dual-branch module for adaptive geometry-motion fusion to capture spatiotemporal dependencies for mapping infarcted region. Furthermore, we introduce multi-scale supervision utilizing an AHA-17 segment-guided cross-attention mechanism to steer the prediction, ensuring biophysically consistent reconstruction. Experimental results on 225 cine MRIs demonstrated that the proposed 3D MI reconstruction achieved high performance with an average Dice score of 0.678 $\pm$ 0.011. In the downstream in-silico electrophysiological simulation evaluations, the results were highly consistent with the LGE-derived ground truth, highlighting the great potential of the proposed model for contrast-free scar characterization and seamless integration into CDT modeling. The code will be released publicly upon acceptance of the manuscript for publication.
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