用生理原型引导注意力,实现无需校准的可解释脑机接口分类
ERP-XTTN: Interpretable Prototype-Guided Cross-Attention for Cross-Subject ERP Classification

- 基于差异波峰值自动构建生理原型,通过跨注意力路由信号到原型
- 在3通道下跨被试分类平均提升0.025 AUROC,错误样本具神经可解释性
- 决策直接依赖原型内容,适合对模型可解释性要求高的临床应用
无需校准的可解释脑机接口分类器在跨被试场景中仍属挑战。本文提出ERP-XTTN,一种基于原型的跨注意力架构,通过仅查询-键的跨注意力将输入脑电峰信号路由至固定差异波原型,无值投影。分类直接基于原型相似度与成分幅值,确保原型内容始终参与决策。原型由训练集平均差异波的显著极值自动提取。在三个公开数据集(BNCI Horizon 2020、HRI Cursor、ERP CORE)上评估,涵盖八种ERP成分(ERN、LRP、ErrP、N170、P300、N2pc、MMN、N400)。采用单被试留一交叉验证(LOSO),三通道蒙太奇下因果滤波,对比EEGNet、EEG-Deformer、EPMN及xDawn+黎曼几何。最佳基线与ERP-XTTN间平均性能差距为0.025 AUROC。原型干预证实决策依赖原型内容而非注意力路由模式本身。误报在波形上更接近真阳性而非真阴性,表明分类错误具有神经生理可解释性。ERP-XTTN在因果、免校准条件下实现多样化ERP形态的泛化,保持竞争力且决策可直接观测。本研究为首次在ERP CORE上开展的时序级LOSO基准测试。
原文摘要 · Abstract (English)
Interpretable brain-computer interface classifiers that generalize across subjects without calibration remain an open challenge. We evaluated whether prototype-based cross-attention can provide competitive, inherently interpretable ERP classification across paradigms under deployment-compatible conditions. We propose ERP-XTTN (ERP Cross-Attention), a cross-attention architecture that routes input EEG peaks to fixed difference-wave prototypes via query-key-only cross-attention with no value projection. Classification is based directly on prototype similarity and a separate measure of component amplitude, so that prototype content contributes to every decision by construction. Prototypes are derived automatically from prominent extrema in the training-fold grand-average difference wave. We evaluated across three public sources (BNCI Horizon 2020, HRI Cursor, and ERP CORE) encompassing eight ERP components (ERN, LRP, ErrP, N170, P300, N2pc, MMN, N400). Evaluations used LOSO cross-validation with causal filtering at a three-channel montage, compared against EEGNet, EEG-Deformer, EPMN, and xDAWN with Riemannian geometry. The mean performance gap between the best baseline and ERP-XTTN was 0.025 AUROC. Prototype interventions confirmed that decisions depend on prototype content rather than on the routing attention pattern alone. False positives morphologically resembled true positives more than true negatives did, so classification errors are neurophysiologically explicable. ERP-XTTN generalizes across diverse ERP morphologies under causal, calibration-free conditions, while retaining competitive performance and decisions that depend directly on physiological prototype content. Unlike post-hoc explanation methods for black-box models, the basis of each decision is directly observable in the trained model. To our knowledge, this is the first epoch-level LOSO benchmark on ERP CORE.
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