提出可精准识别肾部病灶的3D分割模型,支持按病灶生成临床报告。
Multi-Granularity 3D Kidney Lesion Characterization from CT Volumes

- 将肾病灶识别建模为每侧肾脏独立预测病灶集合的任务。
- 在788例患者数据上实现双侧异常检测AUC达0.799,囊肿病灶检测平均精度0.190。
- 强调腹部预训练对性能提升关键,适合医学影像自动化分析场景。
放射科报告描述肾病灶时包含类型、大小、增强和衰减等特征,但现有3D方法仅能进行患者或器官级别的预测。本文将肾CT表征重构为基于病灶的集合预测任务:一个模型可输出每侧肾脏中数量可变的病灶,每个病灶包含四个临床属性。研究收集了来自一所学术医疗中心的2,619例CT体积数据(共788名患者),并标注了多粒度的病灶级与侧别标签,使用KiTS23(489例)进行零样本外部验证。提出LesionDETR,一种类DETR架构,采用大小-距离匈牙利匹配及分层损失,将每个槽位输出聚合至侧别目标。在四种输入表示和六种编码器初始化下,两个设计选择占优:输入通道加入分割掩码,以及同域腹部预训练(SuPreM);通用大语料预训练表现不优于随机初始化。LesionDETR在UF-Health上达到双侧异常检测AUC 0.799±0.009,KiTS23上达0.817±0.072。计数条件变体在囊肿病灶上实现每病灶mAP 0.190±0.083;稀有实性病灶的准确率仍处于噪声水平,表明下一瓶颈在于针对性数据采集而非模型架构。该框架可生成经验证的病灶级预测结果,用于下游结构化报告生成。
原文摘要 · Abstract (English)
Radiology reports describe kidney lesions by type, size, enhancement, and attenuation, yet existing 3D methods predict only at the patient or organ level. We reformulate kidney CT characterization as a per-lesion set-prediction task: one model emits a variable number of lesions per kidney, each with four clinical attributes. We curated 2,619 CT volumes from 788 patients at one academic medical center, with multi-granularity side- and per-lesion labels, and used KiTS23 (489 cases) for zero-shot external validation. We propose \textbf{LesionDETR}, a DETR-style architecture with size-distance Hungarian matching and a hierarchical loss that aggregates per-slot outputs to side-level objectives. Across four input representations and six encoder initializations, two design choices dominate: a segmentation mask as an input channel, and same-domain abdominal pretraining (SuPreM); generic large-corpus pretraining is no better than random initialization. LesionDETR reaches bilateral side-level abnormality AUC $0.799 \pm 0.009$ on UF-Health and $0.817 \pm 0.072$ on KiTS23. A count-conditioned variant reaches per-lesion mAP $0.190 \pm 0.083$ on cystic lesions; rare solid-lesion AP stays at the noise floor, pointing to targeted data collection, not architecture, as the next bottleneck. The framework yields verified per-lesion predictions for downstream structured report generation.
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