arXiv:2606.04632cs.LGcs.CL2026-06

用大模型做呼吸机决策仲裁,让治疗更安全可解释。

VentAgent: When LLMs Learn to Breathe -- Multi-Objective Arbitration for ARDS Ventilation

论文配图:VentAgent: When LLMs Learn to Breathe -- Multi-Objective Arbitration for ARDS Ventilation
图 1 · 摘自论文原文
  • 用大模型分阶段协调氧合、肺保护等多重目标
  • 在模拟器上优于顶尖强化学习与传统控制方法
  • 输出可读的推理链条,适合临床医生信任使用

急性呼吸窘迫综合征(ARDS)机械通气需平衡氧合、肺保护和酸碱稳态等多重生理目标。现有数据驱动方法常受回顾性电子病历(EHR)模仿偏差影响,错误关联稳定患者常见的通气设置与生存率,难以泛化到变异或分布外情况。标准强化学习也因危重症中对抗性权衡而表现不佳,且策略不透明。为此,我们提出VentAgent,一种层级化框架,由大语言模型(LLMs)作为通气决策的透明仲裁者。将通气控制重构为动态多目标仲裁过程,分解为感知、规划、协调三阶段。借助LLM语义推理能力,整合异构专家经验,通过显式协调机制化解临床优先级冲突。在高保真生理模拟器上的评估显示,VentAgent超越先进强化学习与经典控制基线。同时,其决策转化为人类可读的推理链,提供更安全、可解释、可适应的危重症自动化范式。

原文摘要 · Abstract (English)

Mechanical ventilation for Acute Respiratory Distress Syndrome (ARDS) requires balancing competing physiological goals, including oxygenation, lung protection, and acid-base homeostasis. However, current data-driven methods, especially those imitating retrospective Electronic Health Records (EHR), often suffer from imitation bias. They may capture superficial correlations from inconsistent clinical demonstrations, such as associating passive ventilator settings with survival because such settings are common in stable patients, and thus fail to generalize to volatile or out-of-distribution phenotypes. Standard Reinforcement Learning (RL) methods also struggle with the adversarial trade-offs of critical care and often produce opaque policies with limited clinical interpretability. To address these limitations, we introduce VentAgent, a hierarchical framework in which Large Language Models (LLMs) act as transparent arbitrators for mechanical ventilation. We reformulate ventilation control as a dynamic Multi-Objective Arbitration process rather than single-objective optimization. VentAgent decomposes decision-making into three interpretable stages: Perception, Planning, and Orchestration. By leveraging the semantic reasoning capabilities of LLMs, it synthesizes strategies from heterogeneous experts and resolves conflicting clinical priorities through an explicit coordination mechanism. Evaluations on a high-fidelity physiological simulator show that VentAgent outperforms state-of-the-art RL and classical control baselines. Moreover, it converts control decisions into human-readable reasoning chains, offering a safer, more interpretable, and adaptable paradigm for critical care automation.

呼吸机控制大模型多目标优化临床决策

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