用进化算法自动优化医疗决策流程,效果优于人工设计。
LLM-Guided Evolution for Medical Decision Pipelines

- 通过进化搜索生成可执行的医疗决策程序,无需微调。
- 分诊任务准确率提升至87.1%,急诊召回率达0.97。
- 结果可解释,适合医疗系统开发者与临床研究者参考。
将大语言模型应用于临床工作流常需昂贵的微调或手动提示工程。本文研究在推理阶段使用LLM引导的MAP-Elites进化方法,作为发现医疗决策策略的替代方案,并提供代码仓库(https://github.com/univanxx/llm_guided_evo_medical)。我们将紧急分诊、交互式问诊和医学图像分类建模为基于任务特定适应度函数的可执行实体进化搜索。在所有三个场景中,进化策略在实际约束下均优于人工设计基线。在分诊任务中,演化程序将半格兰准确率从77.3%提升至87.1%,急诊召回率从0.60提升至0.97,同时改善了安全加权的持留集MIMIC-ESI表现。在交互式问诊中,演化策略在Llama-3、Qwen-3.5和Gemma-4上均提升了准确率-成本前沿,并成功迁移至未见的iCRAFTMD数据集。在PneumoniaMNIST上,仅提示演进提升了冻结的MedGemma视觉语言模型性能,同时保持严格的JSON输出格式。定性分析表明,性能提升源于可解释的程序级机制、校准的分诊阈值、针对性证据获取、选择性承诺以及面向目标的视觉决策规则,而非简单的提示重述。
原文摘要 · Abstract (English)
Adapting large language models (LLMs) to clinical workflows often requires costly fine-tuning or manual prompt and pipeline engineering. We study LLM-guided MAP-Elites evolution as an inference-time alternative for discovering medical decision strategies and provide an implementation repository at https://github.com/univanxx/llm_guided_evo_medical. We formulate urgency triage, interactive consultation, and medical image classification as evolutionary searches over executable artifacts optimized by task-specific fitness functions. Across all three settings, evolution improves over manually designed baselines under practical constraints. In triage, evolved programs increase Semigran accuracy from $77.3\%$ to $87.1\%$ and emergency recall from $0.60$ to $0.97$, while improving safety-weighted held-out MIMIC-ESI performance. In interactive consultation, evolved policies improve the accuracy--cost frontier across Llama-3, Qwen-3.5, and Gemma-4 and transfer to held-out iCRAFTMD. In PneumoniaMNIST, prompt-only evolution improves frozen MedGemma VLMs while preserving strict JSON outputs. Qualitative analysis shows that the gains come from interpretable program-level mechanisms, calibrated triage boundaries, targeted evidence acquisition, selective commitment, and finding-oriented visual decision rules, rather than superficial prompt rewording alone.
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