用反事实推理生成个性化餐食建议,帮健康人控制餐后高血糖。
MetaPlate: Counterfactual-Guided RAG-LLM Tool for Personalized Food Recommendation and Hyperglycemia Prevention

- 基于反事实优化调整餐食宏量营养素,使血糖≤140 mg/dL
- 融合CGM、可穿戴数据和用户输入,为25人定制方案
- 结合LLM与食品数据库,输出可读性强的实用建议
餐后高血糖是代谢紊乱的关键风险因素;现有饮食建议多为静态、不具操作性且个性化不足,难以执行或效果有限。尽管近年研究利用连续血糖监测(CGM)和机器学习预测血糖反应,但多为预测性而缺乏可行动指导。推荐系统常与用户目标脱节,需大量输入。本文提出MetaPlate,一种基于反事实解释(CF)引导、上下文感知的决策支持框架,通过整合CGM读数、可穿戴生理信号及用户提供的餐食信息,建模餐前状态,生成个性化餐食建议以减轻餐后血糖波动。机器学习模型预测血糖反应,反事实优化模块调整宏量营养素比例,确保血糖维持在≤140 mg/dL目标范围内。基于LLM的检索增强生成(RAG)层通过约束搜索美国农业部食物数据库,生成人类可读建议。我们通过注册营养师(RDs)参与的结构化评估,对比提示优化前后表现,结果显示餐食真实性、份量适宜性和推荐接受度显著提升,专家反馈表明从临床不切实际转为可操作、情境适配的建议。研究强调领域知识与结构化约束在LLM系统中的重要性,凸显MetaPlate作为实时个性化饮食决策支持工具的潜力。
原文摘要 · Abstract (English)
Postprandial hyperglycemia is a key risk factor for metabolic disorders; however, existing dietary guidance is often static, impractical, and insufficiently personalized, providing recommendations that are difficult to follow or not impactful. While recent advances leverage continuous glucose monitoring (CGM) and machine learning to predict glycemic responses, these approaches are largely predictive and lack actionable guidance. Moreover, recommendation systems are often misaligned with user goals and require extensive input. We present MetaPlate, a counterfactual explanation (CF) guided, context-aware decision-support framework that generates personalized meal recommendations to mitigate postprandial glucose excursions in healthy adults. MetaPlate integrates multimodal data, including CGM readings, wearable-derived physiological signals, and user-provided meal inputs from $25$ individuals to model pre-meal context. A machine learning model predicts glucose response, while a CF optimization module adjusts meal composition modifying macronutrient amounts to maintain glucose levels within a target range ($\leq 140$ mg/dL). An LLM-based retrieval-augmented generation (RAG) layer enhances interpretability by producing human-readable recommendations using constrained search of the USDA food database. We evaluate MetaPlate via a structured expert-in-the-loop assessment with registered dietitians (RDs), comparing performance before and after prompt refinement. Results show improvements in meal realism, portion suitability, and recommendation likelihood, with expert feedback indicating a shift from clinically implausible outputs to actionable, contextually appropriate recommendations. Our findings emphasize the importance of domain knowledge and structured constraints in LLM-driven systems and highlight the potential of MetaPlate as a real-time personalized dietary decision-support tool.
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