系统梳理神经活动动态建模的机器学习方法,助力解析大脑信息处理机制。
Machine Learning Methods for Studying Latent Neural Activity Dynamics
- 按单区域动态、多区域通信、行为对齐三类组织模型发展脉络
- 涵盖从线性系统到Transformer等大模型的全链条方法体系
- 适合脑科学与机器学习交叉研究者参考,尤其关注可解释性与因果推断
近年来脑记录技术的进步推动了对大规模神经元群体潜在结构解码的需求。本文全面综述了潜在变量模型(LVMs)的发展历程,从早期状态空间模型演进至近年深度生成模型。文献被划分为三个密切相关领域:(1) 单区域潜在动态,包括线性动力系统、循环神经网络(RNNs)和神经微分方程(ODEs);(2) 多区域通信,采用概率与子空间方法研究不同脑区间的信息传递,考虑突触传播延迟与网络连接;(3) 行为对齐建模,通过监督或对比学习分离与任务表现相关的神经活动与其他内部状态。此外还涵盖基于大规模预训练的神经基础模型,如Transformer与扩散模型,在跨被试场景中表现出色。最后讨论基准测试、评估标准及开放挑战,如识别因果关系或通信方向性,以促进可解释脑动态与可靠神经解码的融合。
原文摘要 · Abstract (English)
Recent developments in brain recording are driving a demand for machine learning tools capable of decoding the latent structure of large populations of neurons. In this paper, we provide a comprehensive survey that outlines the trajectory of Latent Variable Models (LVMs) from early state-space models to more recent deep generative models. We organize the literature into three closely related domains: (1) Single-Region Latent Dynamics, which includes models such as linear dynamical systems to more complex dynamics represented by Recurrent Neural Networks (RNNs) and Neural Ordinary Differential Equations (ODEs); (2) Multi-Region Communication, which employs probabilistic as well as subspace methods to study how information is transferred across different brain areas considering synaptic propagation delays and network connectivity; and (3) Behavior-Aligned Modeling, which seeks to disentangle neural activity related to task performance from other internal states via supervised or contrastive learning. This survey also includes large-scale neural foundation models, such as Transformers and diffusion models, that rely on large-scale pre-training for optimal performance across subjects. Finally, we conclude and discuss benchmarks, evaluation criteria, and open challenges, such as the ability to identify causal links or directionality of communication, to facilitate future research for bridging interpretable brain dynamics with reliable neural decoding.
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