用生理特征增强的Transformer模型,从指尖脉搏波精准估算无袖带血压。
DMT: Demographic Conditioning, Morphology-Enhanced Transformer for Cuffless Blood Pressure Estimation from PPG Signals

- 通过注意力机制捕捉多周期脉搏波长期依赖关系
- 在PulseDB数据集上实现收缩压4.56毫米汞柱、舒张压2.62毫米汞柱误差
- 融合年龄性别等人口统计信息,适合临床可部署的连续血压监测
血压是心血管风险评估与治疗决策的关键指标,光电容积脉搏波(PPG)为低成本、可穿戴式无袖带血压估算提供了可能。然而,尽管近期取得进展,多数基于PPG的模型仅通过血压回归训练,可能依赖幅度主导的捷径。此外,系统性调节血管顺应性的年龄、性别等人种协变量通常仅通过后期融合加入,限制了个体化表征学习。本文提出一种基于Transformer的无袖带血压估算网络,利用自注意力机制捕捉多个心动周期间的长程依赖。为建模个体差异,通过FiLM风格特征调制,在Transformer块的注意力与前馈子层中引入人口统计信息。同时,增加形态学辅助头,引导模型关注与动脉僵硬和波反射相关的波形特征。在大规模PulseDB数据集的校准评估协议下,该方法在收缩压上达到4.56毫米汞柱的平均绝对误差,舒张压为2.62毫米汞柱,相比先前的人口统计增强基线分别降低47%和50%。所提轻量级单传感器模型支持校准启用场景下的可扩展、临床可落地的无袖带血压估算。
原文摘要 · Abstract (English)
Blood pressure (BP) is a key marker for cardiovascular risk assessment and therapeutic decision-making, and Photoplethysmography (PPG) enables low-cost, wearable-friendly cuffless BP estimation. However, even with recent progress, many PPG-based models are trained with BP regression alone and may rely on amplitude-dominated shortcuts. In addition, demographic covariates that systematically modulate vascular compliance are often incorporated only via late fusion, limiting subject-specific representation learning. We propose a Transformer-based network for cuffless BP estimation from PPG signal, leveraging self-attention to capture long-range dependencies across multiple cardiac cycles. To account for subject-specific vascular differences, the model is conditioned on demographics via FiLM-style feature modulation applied through the attention and feed-forward sublayers of Transformer blocks. In addition, we add an auxiliary morphology head to guide the model to attend to BP-relevant waveform morphology associated with arterial stiffness and wave reflection. Under calibration-based evaluation protocols on the large-scale PulseDB dataset, the proposed method achieves MAE of 4.56 mmHg for systolic BP and 2.62 mmHg for diastolic BP, reducing errors by 47% and 50% compared with prior demographic-enhanced PPG baselines. The resulting lightweight, single-sensor model supports scalable and clinically grounded cuffless BP estimation in calibration-enabled deployment settings.
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