通过遮蔽邻近电极,量化脑电信号中局部与分布式信息的比例。
Spatially Masked Regression Reveals Local and Distributed Predictability in Electrophysiological Recordings

- 用可调节遮蔽区的回归方法,分离电极信号中的局部与全局贡献。
- 即使屏蔽邻近电极,仍能高精度重建信号,说明存在广泛分布的信息。
- 适用于颅内和头皮脑电,适合研究神经信号的空间组织机制。
神经记录常被视为局部测量,但任一电极信号也可能反映整个网络的结构性活动。本研究提出空间遮蔽回归(SMR)框架,通过排除目标电极附近的可配置区域,从其余电极重建其时间序列。逐步扩大遮蔽范围,使空间局部性成为实验控制变量,以量化在屏蔽邻近通道后仍可预测的信息量。在具有异质电极覆盖的颅内脑电(iEEG)和标准排列的运动皮层头皮脑电(EEG)上应用,发现两者的被试内重建效果显著,即便移除邻近电极,仍存在明显残余可预测性,且跨被试迁移能力在EEG中远强于iEEG。遮蔽分析显示邻近电极贡献大,但不足以解释全部预测性能,表明单个通道同时反映局部冗余与广泛分布结构。破坏相位或时间顺序的随机替代数据显著降低性能,支持结论:SMR依赖于结构化的时空与跨通道组织,而非仅边际统计特征。该结果确立了SMR作为量化记录中局部与分布式信息平衡的可解释框架。
原文摘要 · Abstract (English)
Neural recordings are often interpreted as local measurements, yet the signal at any one sensor can also reflect structured activity distributed across the broader network. This raises a basic question: to what extent does an electrode's signal reflect local versus distributed information in the underlying system? More specifically, how much of an electrode's activity is carried by its immediate neighborhood, and how much is embedded more broadly across the array? We address this with a Spatially Masked Regression (SMR) framework that reconstructs each electrode's timeseries from the remaining electrodes while excluding a configurable neighborhood around the target. By progressively increasing this mask, spatial locality becomes an experimental control for quantifying how much predictive information survives after nearby channels are withheld. We apply SMR to intracranial EEG with heterogeneous electrode coverage and to scalp EEG with standardized montages over sensorimotor cortex. Using distance correlation between original and reconstructed signals, we find strong within-subject reconstruction in both modalities, substantial residual predictability even when local neighbors are excluded, and markedly stronger cross-subject transfer in EEG than in iEEG. Masking shows that nearby electrodes contribute strongly to reconstruction but do not account for all of it, indicating that individual channels reflect both local redundancy and broader distributed structure. Surrogates that preserve selected marginal or spectral properties while disrupting phase structure or temporal ordering substantially reduce performance, supporting the conclusion that SMR depends on structured temporal and cross-channel organization rather than on marginal statistics alone. These results position SMR as an interpretable framework for quantifying the balance between local and distributed information in recordings.
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