基于注意力机制估计个体用药效果概率,支持多剂量场景
Attention-Based Estimation of the Individual Treatment Benefit Probability under Dose Variation

- 用相似患者配对构建伪标签,通过注意力机制聚合
- 在真实与合成数据上,注意力方法优于核回归,尤其在小样本下
- 适合临床个性化用药决策,代码开源可复现
估计个体患者治疗优于对照的概率(即个体治疗受益概率,IPTB),为临床提供直观的个性化评估方式。然而,现有方法多局限于二分类治疗场景,难以应对临床中普遍存在的多剂量干预。本文提出一种支持离散剂量水平的广义框架——Dose-AIPTB(基于注意力的IPTB估计),将问题重构为个体治疗效应符号的二分类任务。通过协变量相似性配对生成伪标签,并利用注意力机制或Nadaraya-Watson核回归进行聚合,自然扩展至多剂量情形。在存在协变量偏移、不同样本量及异质结果的真实与合成数据上进行实验,结果表明注意力聚合始终优于核回归方法。该框架为基于个体受益概率的个性化剂量选择提供了理论基础。代码已公开于https://github.com/NTAILab/AIPTBDose。
原文摘要 · Abstract (English)
Estimating the probability that a treatment outperforms a control for an individual patient, called the Individual Probability of Treatment Benefit (IPTB), offers a clinically intuitive alternative to population-average metrics. However, existing methods for IPTB estimation are largely confined to binary treatment settings, despite the prevalence of dose-varying interventions in clinical practice. We propose a general framework for IPTB estimation with ordinal outcomes under discrete dose assignments, called Dose-AIPTB (Dose Attention-based IPTB). Our approach recasts the problem as binary classification over the unobserved sign of the individual treatment effect, constructing pseudo-labels from covariate-similar pairwise comparisons and aggregating them via attention mechanisms or Nadaraya-Watson kernel regression. This formulation naturally accommodates multiple discrete dose levels, extending beyond the binary treatment paradigm. Through numerical experiments on real-world and synthetic data under covariate shift, varying sample sizes, and heterogeneous outcomes, we demonstrate that attention-based aggregation consistently outperforms kernel alternatives. The framework provides a foundation for personalized dose selection grounded in individual-level benefit probabilities. Codes implementing the model are publicly available at https://github.com/NTAILab/AIPTBDose.
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