医学知识图谱助力临床决策,提升诊疗个性化与可解释性。
Semantic Reasoning in Medicine: The Role of Knowledge Graphs Across Five Key Domains

- 构建疾病、药物、症状等实体的语义关系网络
- 在诊断推荐和精准医疗中提升推理准确性和可解释性
- 适合医疗AI研究者与临床决策系统开发者参考
知识图谱(KGs)作为整合复杂生物医学与临床数据的有力工具,在医疗领域展现出巨大潜力。通过建模疾病、药物、症状与患者记录等实体间的结构化关系,知识图谱为临床决策、预测、推荐及个性化医疗提供了语义基础。近年来,其应用涵盖临床决策支持、疾病与治疗结果预测、健康推荐系统、精准医学和医学问答系统,显著增强可解释性、语义一致性和个体化推理能力。同时,研究也聚焦于从电子病历、临床文本、生物医学文献和网络资源中构建知识图谱,采用本体、语义网技术、深度学习信息抽取及混合神经符号方法。尽管取得进展,仍面临知识覆盖有限、异构数据对齐困难、密集多关系图上推理与表示学习方法脆弱,以及隐私、偏见与责任问题等挑战。本文从应用与方法双维度综述当前医学知识图谱研究,分析其优势、技术基础与局限,梳理关键开放问题,旨在引导未来医学AI系统的研发,并推动其安全有效融入医疗实践。
原文摘要 · Abstract (English)
Knowledge graphs (KGs) have emerged as a promising solution for integrating and reasoning over complex biomedical and clinical data in healthcare. By representing structured relationships among entities such as diseases, drugs, symptoms, and patient records, KGs provide a semantic backbone for decision-making, prediction, recommendation, and personalized care. Recent advances have demonstrated their utility across diverse medical applications--including clinical decision support systems, disease and treatment outcome prediction, health recommender systems, precision medicine, and medical question answering--where KGs often enhance interpretability, semantic coherence, and patient-specific reasoning. In parallel, a growing body of work focuses on medical KG generation itself, proposing frameworks that construct graphs from EHRs, clinical narratives, biomedical literature, and web resources using ontologies, semantic web technologies, deep-learning-based information extraction, and hybrid neuro-symbolic pipelines. Despite this progress, significant challenges remain, including limited and fragmented knowledge coverage, difficulties in aligning heterogeneous data sources, the fragility of current reasoning and representation-learning methods on dense multi-relational graphs, and unresolved issues related to privacy, bias, and accountability. This survey reviews and categorizes current research on KGs in medicine along both application-oriented and methodology-oriented dimensions, discusses their benefits and technical foundations, and outlines key limitations and open research directions. By analyzing trends, architectures, and evaluation practices, this work aims to guide future developments in KG-driven medical AI systems and support their safe and effective integration into healthcare environments.
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