用患者级临床信息引导心率波形学习,提升可泛化性。
CAP: Towards PPG Universal Representation Learning with Patient-level Supervision

- 通过跨模态对比学习,将心率信号与患者整体健康状态对齐
- 在呼吸率预测任务上相对领先模型提升87.6%
- 适合需要高鲁棒性和临床可解释性的可穿戴健康监测场景
光电体积描记法(PPG)在可穿戴健康监测和临床决策支持中起核心作用。然而,现有通用PPG表征学习方法多聚焦于信号级目标,常忽视患者级健康背景,限制了其在复杂临床任务和异质人群中的泛化能力。为此,我们通过整合碎片化的医疗记录,构建了一个大规模的配对PPG-EHR多模态数据集,形成连贯的患者级电子健康记录(EHR)。基于此资源,我们提出临床锚定的PPG预训练方法(CAP)。在预训练阶段,CAP通过跨模态对比对齐,将PPG表征锚定至患者级临床语义,引导编码器超越波形拟合,转向建模患者整体生理状态的一致性。在下游适配阶段,预训练的PPG编码器提供具有临床基础的表征,增强归纳偏置,提升鲁棒性与可迁移性。实验表明,CAP在四个不同下游任务中持续优于强基线模型,尤其在呼吸率预测任务上实现高达87.6%的相对提升,所有任务平均相对提升26.7%。我们通过消融实验和多种可视化分析进一步增强了方法的可解释性。代码已公开于https://github.com/gody123gody/CAP。
原文摘要 · Abstract (English)
Photoplethysmography (PPG) plays a central role in wearable health monitoring and clinical decision support. Yet existing approaches to universal PPG representation learning largely focus on signal-level objectives and often overlook patient-level health context, which limits generalization to complex clinical tasks and heterogeneous cohorts. To address this gap, we construct a large-scale paired PPG-EHR multimodal dataset by distilling fragmented medical histories and clinical records into cohesive, patient-level electronic health records (EHR). Building on this resource, we propose Clinical Anchored Pretraining for PPG (CAP). During pretraining, CAP performs cross-modal contrastive alignment that anchors PPG representations to patient-level clinical semantics, guiding the encoder beyond waveform fitting toward modeling consistency in a patient's overall physiological state. During downstream adaptation, the pretrained PPG encoder provides clinically grounded representations that strengthen inductive bias and improve robustness and transferability. Experiments demonstrate that CAP consistently outperforms strong baselines on four diverse downstream tasks. CAP achieves a particularly large gain on respiratory rate prediction (up to +87.6% relative improvement over the state-of-the-art baseline) and delivers an average relative +26.7% across all tasks. We further enhance the interpretability of our approach through comprehensive analyses, including ablations and multiple complementary visualizations of the learned representations. The code for our experiments is available at: https://github.com/gody123gody/CAP .
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