用7个标注体数据,让SAM3自动分割4DCT肺心结构,精准且省算力。
Parameter-Efficient Adaptation of SAM 3 for Automated ITV Generation from 4DCT Images

- 用低秩适配(LoRA)轻量微调SAM3,仅需7个标注数据即可对齐医学领域
- 中位Dice达0.968(肺)和0.910(心),95%分位豪斯多夫距离<3毫米
- 通过时序滤波抑制伪影,单卡训练,适合临床自适应放疗场景
四维计算机断层扫描(4DCT)捕捉胸腔解剖的完整呼吸周期,但现有内部靶区勾画流程将各相位独立处理,丢失时间一致性,导致轮廓易受相位特异性伪影影响。本文提出一种轻量级框架,通过低秩适配(LoRA)对分割一切模型3(SAM 3)进行参数高效微调,仅用七个标注的3D CT体积即实现文本提示分割与医学领域的对齐。此外,框架引入硬负样本挖掘策略,提升低对比度胸腔区域的边界判别能力。推理阶段,通过相位一致的时序滤波与空间连通性分析优化逐相预测。由于呼吸运动连续且周期性,真实解剖在连续相位块中出现,而瞬态伪影则零星分布,因而被有效抑制。在肺部和心脏结构上的实验显示,中位Dice分数分别为0.968和0.910,95%分位豪斯多夫距离分别为0.998毫米和2.931毫米。所提框架有效消除未适配SAM3零样本推理中的严重假阳性预测。仅需七个标注体积,框架仍保持超过95%的全数据精度,整个流程可在单张消费级GPU上训练,展示了一种可扩展、数据高效的自适应放疗解决方案。
原文摘要 · Abstract (English)
Four-dimensional computed tomography (4DCT) captures the full respiratory cycle of thoracic anatomy, yet current Internal Target Volume contouring workflows process each phase in isolation, discarding temporal coherence and leaving contours vulnerable to phase-specific artifacts. We present a lightweight framework that applies parameter-efficient fine-tuning to the Segment Anything Model 3 (SAM 3) via low-rank adaptation (LoRA) to align its text-prompted segmentation with the medical domain using only seven annotated 3D CT volumes. Furthermore, the framework incorporates a hard negative mining strategy to improve boundary discrimination in low-contrast thoracic regions. At inference, phase-wise predictions are refined through phase-coherent temporal filtering and spatial connectivity analysis. Since respiratory motion is continuous and periodic, genuine anatomy appears in contiguous blocks of phases, whereas transient artifacts appear sporadically and are thus effectively suppressed. Experiments on pulmonary and cardiac structures yield median Dice scores of 0.968 and 0.910 with 95th-percentile Hausdorff distances of 0.998 mm and 2.931 mm, respectively. The proposed framework effectively eliminates the severe false-positive predictions inherent in the zero-shot inference of the unadapted SAM 3. With only seven annotated volumes, the framework retains over 95% of full-data accuracy, and the entire pipeline is trainable on a single consumer-grade GPU, demonstrating a scalable, data-efficient solution for adaptive radiotherapy.
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