arXiv:2606.15692eess.IV2026-06

用球面扩散模型生成匹配的脑皮层数据,提升阿尔茨海默病多任务分析效果。

A Surface-based Multimodal Framework for Multitask Analysis in Alzheimer's Disease

论文配图:A Surface-based Multimodal Framework for Multitask Analysis in Alzheimer's Disease
图 1 · 摘自论文原文
  • 基于球面扩散生成配对的皮层厚度与Tau-PET数据,保持解剖对应性。
  • 在ADNI数据集上五项任务均优于六种基线模型,性能稳定提升。
  • 适合从事神经退行性疾病影像分析的研究者使用。

阿尔茨海默病(AD)是一种进行性神经退行性疾病,纵向分析对于早期检测和有效干预至关重要。开发能够进行多模态、多任务分析的模型,有助于更全面理解AD进展。然而,多模态学习仍面临跨模态错位、皮层数据的非欧几里得表面表示以及小样本临床环境中数据有限等挑战。本文提出一种增强型球面数据驱动的多任务AD分析框架。首先训练一个球面扩散模型,生成配对的皮层厚度与Tau PET标准化摄取值比(SUVR)数据,在皮层表面上实现结构一致的多模态数据增强,同时保持解剖对应关系。随后利用增强数据训练对比学习模型,学习对齐且融合的跨模态表示,强化多模态整合并促进更均衡的表示学习。学习到的影像特征进一步与表格型认知评估及人口统计变量融合,通过上下文学习模型完成分类与回归任务,无需针对特定任务微调。在阿尔茨海默病神经成像计划(ADNI)数据集(n = 802)上的实验表明,该方法在五项诊断与纵向任务中均表现出一致的性能提升,优于六种基线模型。

原文摘要 · Abstract (English)

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder, and longitudinal analysis is critical for early detection and effective intervention. Developing models capable of multimodal and multitask analysis enables a more comprehensive understanding of AD progression. However, multimodal learning remains challenged by cross-modal misalignment, non-Euclidean surface representations of cortical data, and limited data availability in small-sample clinical settings. In this work, we propose an augmented spherical data-driven multimodal framework for multitask AD analysis. A spherical diffusion model is first trained to generate paired cortical thickness and Tau PET Standardized Uptake Value Ratio (SUVR) data, enabling structurally consistent multimodal augmentation on cortical surfaces while preserving anatomical correspondence. The augmented data are subsequently used to train a contrastive learning model that learns aligned and fused cross-modal representations. This design strengthens multimodal integration and encourages more balanced representation learning. The learned imaging features are further integrated with tabular cognitive assessments and demographic variables, and processed using an in-context learning model to perform both classification and regression tasks without task-specific fine-tuning. Experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset ($n = 802$) demonstrate consistent performance improvements across five diagnostic and longitudinal tasks, outperforming six baseline models.

阿尔茨海默病多模态分析扩散模型脑表面建模

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