提出可重复生成多模态解剖图像投影的新方法,用于颌骨运动等临床分析。
Transformation-driven generation of comparable projection images from multimodal anatomical scenes

- 基于显式空间变换的框架,将解剖结构直接映射到投影空间。
- 在相同成像假设下生成可直接比较的虚拟影像,支持多种解剖构型。
- 适用于颅面分析中的颌骨运动与治疗重定位研究。
本文针对异质解剖场景中组件独立空间变换下的可重复投影观测计算难题,提出一种基于变换驱动的多模态解剖数据合成投影成像框架,并在下颌运动场景中验证。不同于传统数字重建放射图(DRR)方法主要关注配准、投影真实感或渲染效率,该方法将投影成像视为作用于显式表示解剖场景的观测过程。可独立变换的体素与基于表面的解剖对象嵌入共享场景表示中,通过显式变换直接传播至投影空间。投影几何、采集建模、材料解释与图像呈现保持显式分离,支持方法假设的可控探索,同时确保生成投影的可重复性与直接可比性。重点聚焦于颅面分析相关的变换驱动场景,包括下颌运动与治疗重定位。利用包含CT/CBCT体积、分割结构、表面模型及辅助解剖/治疗对象的共享参考解剖场景,该框架可在保持相同成像假设的前提下,生成来自多种解剖构型的可直接比较的VirtualRTG投影。不追求完全物理真实的放射模拟,而是提供一个可控、可重复的方法学环境,用于研究解剖-投影关系、运动可观测性与变换感知成像流程。
原文摘要 · Abstract (English)
This work addresses the computational problem of generating reproducible projection-space observations from heterogeneous anatomical scenes whose components may undergo independent spatial transformations. We propose a transformation-driven framework for synthetic projection imaging from multimodal anatomical data and demonstrate it on mandibular-motion scenarios. In contrast to conventional Digitally Reconstructed Radiograph (DRR) approaches primarily designed for registration, projection realism, or rendering efficiency, the proposed formulation treats projection imaging as an observation process operating on an explicitly represented anatomical scene. Independently transformable volumetric and surface-based anatomical objects are embedded within a shared scene representation and propagated directly into projection space through explicit transformations. Projection geometry, acquisition modelling, material interpretation, and image presentation remain explicitly separated, enabling controlled exploration of methodological assumptions while preserving reproducibility and direct comparability between generated projections. Particular emphasis is placed on transformation-driven anatomical scenarios relevant to craniofacial analysis, including mandibular motion and therapeutic repositioning. Using a shared anatomical reference scene composed of CT/CBCT volumes, segmented structures, surface models, and auxiliary anatomical or therapeutic objects, the framework enables generation of directly comparable VirtualRTG projections from multiple anatomical configurations while preserving identical imaging assumptions. Rather than aiming at fully physically faithful radiographic simulation, the proposed approach provides a controllable and reproducible methodological environment for studying anatomy--projection relationships, motion observability, and transformation-aware imaging workflows.
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