用稀疏术中数据修正肝脏变形预测,提升手术导航精度
MeiBRD: Meta-Learning Intraoperative Biomechanical Residual Deformation

- 用图神经网络学习残差变形,修正线性生物力学模型
- 在可变形肝假体数据集上优于刚性、物理模型和纯数据驱动方法
- 适合需要高精度术中配准的外科手术导航场景
术中肝脏配准因软组织大变形与测量稀疏而困难。生物力学模型虽能提供先验知识,但因简化假设导致预测偏差;数据驱动方法则面临数据效率低、泛化性差和物理合理性不足问题。本文提出一种混合配准框架,利用稀疏术中对应点自适应调整生物力学先验。不直接学习完整形变场,而是学习一个残差变形函数,用于修正线性生物力学预测,该函数基于3D肝脏网格建模为具有几何感知注意力的图神经扩散函数。为实现稀疏观测的远距离信息传递,将术中测量视为上下文样本,构建输入-输出对,通过前馈元学习器从这些上下文样本中学习残差函数。在可变形肝假体数据集上的实验表明,本方法在配准精度和泛化能力上均优于刚性、生物力学及数据驱动基线,尤其在分布外几何形状和变形情况下表现更优。
原文摘要 · Abstract (English)
Accurate intraoperative liver registration is challenging due to substantial soft-tissue deformation yet sparse intraoperative measurements. Biomechanical models regularize this ill-posedness with prior knowledge but exhibit persistent prediction bias due to simplifying assumptions, while data-driven learning solutions struggle with data efficiency, generalization, and physical plausibility. We propose a hybrid registration framework that adapts a biomechanical prior using sparse intraoperative correspondences. Rather than learning a full deformation field, we learn a residual deformation function that corrects linear biomechanical predictions, modeled as a graph neural diffusion function with geometry-aware attention over the 3D liver mesh. To enable long-range information transfer of sparse observations, we take a novel perspective of sparse intraoperative measurements as \textit{context} samples where input-output pairs of the residual deformation function are fully observed, casting the problem into learning-to-learn this residual function from intraoperative context samples with feedforward meta-learners. Experiments on a deformable liver phantom dataset demonstrate improved registration accuracy and generalization compared to rigid, biomechanical, and data-driven baselines, particularly for out-of-distribution geometries and deformations.
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