arXiv:2606.23461cs.IR2026-06

癌症幸存者运动时心率调节能力下降,真实场景穿戴设备监测更准确。

Analysis of Autonomic Regulation in Cancer Survivors During Daily Physical Activity: A Real-World Wearable ECG Study

论文配图:Analysis of Autonomic Regulation in Cancer Survivors During Daily Physical Activity: A Real-World Wearable ECG Study
图 1 · 摘自论文原文
  • 用可穿戴心电图结合体动传感器,分轻中强度活动并剔除信号劣化段。
  • 幸存者轻度活动时心率高10.5次/分,中度活动时心率变异性下降近一半。
  • 无需人工标注的信号质量评估框架,有效识别高质量数据段。

本研究利用真实世界中可穿戴心电图(ECG)数据,分析乳腺癌幸存者在日常活动中的心率(HR)与心率变异性(HRV)反应。由于运动伪影和信号退化,此类环境中可靠HRV分析极具挑战。为此,我们结合加速度计与陀螺仪数据对活动强度进行分段(轻、中、剧烈),并采用包含R波检测和无标注信号质量评估的稳健ECG处理流程。因剧烈活动导致的HRV估计不可靠,故分析聚焦于轻中强度活动。使用30秒、1分钟和2分钟窗口计算HR与HRV指标,并与健康对照组比较。癌症幸存者在各活动水平均表现出心率升高、HRV降低。轻度活动时,对照组心率95.7 bpm,幸存者达103.4 bpm;中度活动时,RMSSD由39.7 ms降至22.1 ms,SDNN由42.6 ms降至25.1 ms。统计分析显示组间差异显著且效应强烈一致。此外,所提信号质量评估框架能可靠识别高质量片段,实现近乎完美的有效RR比(0.99),无需人工标注。结果表明癌症幸存者存在活动依赖性自主神经调节障碍,凸显运动感知分段与稳健信号控制在真实穿戴环境中的重要性。

原文摘要 · Abstract (English)

This study investigates heart rate (HR) and heart rate variability (HRV) responses to physical activity in breast cancer survivors using wearable electrocardiogram (ECG) data collected in real-world settings. Reliable HRV analysis in such environments is challenging due to motion artifacts and activity-related signal degradation. To address this, we use an approach that combines accelerometer and gyroscope data for activity intensity segmentation (light, moderate, vigorous) with a robust ECG processing pipeline incorporating R-peak detection and annotation-free signal quality assessment. Because vigorous activity produced unreliable HRV estimates, analyses focused on light and moderate activity levels. Using 30 s, 1 min, and 2 min windows, HR and HRV metrics were computed and compared between breast cancer survivors and healthy controls. Cancer survivors consistently exhibited elevated HR and reduced HRV across activity levels. During light activity, HR increased from 95.7 bpm in controls to 103.4 bpm in cancer survivors. Differences became more pronounced during moderate activity, where RMSSD decreased from 39.7 ms to 22.1 ms and SDNN from 42.6 ms to 25.1 ms. Statistical analyses showed significant group differences with strong and consistent effects across observations. In addition, the proposed ECG quality assessment framework reliably identified high-quality signal segments, achieving near-perfect valid RR ratios (0.99) without manual annotations. Overall, these findings demonstrate impaired and activity-dependent autonomic regulation in cancer survivors and highlight the importance of motion-aware activity segmentation and robust ECG quality control for accurate physiological monitoring in real-world wearable settings.

心率变异性可穿戴设备癌症康复生理监测

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