arXiv:2606.23871cs.LGq-bio.QM2026-06

跨机构乳腺癌数据下,联邦生存分析有效且稳定,可兼顾隐私与模型性能。

Federated Survival Analysis in Healthcare: A Multi-Model Evaluation on Cross-Institutional Heterogeneous Breast Cancer Data

论文配图:Federated Survival Analysis in Healthcare: A Multi-Model Evaluation on Cross-Institutional Heterogeneous Breast Cancer Data
图 1 · 摘自论文原文
  • 在多机构异构数据上对比三种生存模型与三种联邦优化策略。
  • 联邦学习性能优于本地训练,部分场景接近甚至超过集中式模型。
  • 随机生存森林表现最优,联邦平均和联邦近似更稳健,适合临床决策。

生存分析对临床决策至关重要,但可靠的时间-事件模型需要大规模多样队列,而单个机构难以满足,且隐私法规限制患者数据集中。联邦学习(FL)通过不交换原始数据即可训练共享模型,提供一种隐私保护方案,但在真实异构条件下用于生存建模的效果尚不明确。本文在跨机构乳腺癌队列上系统评估了联邦生存分析,涵盖三个代表性模型:Cox比例风险模型、DeepSurv和随机生存森林(RSF),并比较了集中式、本地及联邦训练方式,以及三种联邦优化策略(FedAvg、FedProx、FedAdam)。结果表明,联邦学习始终优于本地训练,且在多数情况下接近甚至超过集中式性能;其中,随机生存森林在区分度、校准性和异构客户端鲁棒性方面表现最佳。我们进一步发现性能受客户端分布差异影响,且FedAvg与FedProx优于FedAdam。基于这些发现,提出面向实际应用的决策指南,帮助根据数据、隐私、可解释性与资源约束选择合适模型与训练范式。

原文摘要 · Abstract (English)

Survival analysis is central to clinical decision-making, yet reliable time-to-event models require large, diverse cohorts that are rarely available at a single institution, while privacy regulations restrict the centralization of patient data. Federated learning (FL) offers a privacy-preserving alternative by training shared models without exchanging raw data, but its effectiveness for survival modeling under realistic, heterogeneous conditions remains insufficiently understood. This paper presents a systematic, multi-model evaluation of federated survival analysis on a cross-institutional breast cancer cohort with naturally heterogeneous distributed clients. Three representative survival models, the Cox Proportional Hazards model, DeepSurv, and Random Survival Forest (RSF), are compared across centralized, local, and federated training, and three federated optimization strategies (FedAvg, FedProx, and FedAdam) are assessed for the gradient-based models. Results show that FL consistently outperforms local training and approaches, and occasionally exceeds, centralized performance, while RSF offers the best overall balance of discrimination, calibration, and robustness across heterogeneous clients. We further find that performance depends on the diversity of client distributions, and that FedAvg and FedProx are stronger and more stable than FedAdam. Based on these findings, we derive practical, decision-oriented guidelines mapping data, privacy, interpretability, and resource constraints to recommended model and training-paradigm choices for federated survival modeling in healthcare.

联邦学习生存分析医疗AI异构数据

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