构建双分支图结构,让糖尿病视网膜病变分级可解释。
A Dual Edge Spatial Jacobian Image Graph for Interpretable Diabetic Retinopathy Grading

- 用血管-病灶几何关系和嵌入-生物标志物敏感性双路径建模
- 在2910张APTOS图像上达到0.8312的加权卡帕系数
- 适合用于生成病灶与血管特征关联的科学假设
从彩色眼底照片自动分级糖尿病视网膜病变(DR)可实现良好预测性能,但临床解读不仅需要图像级标签,还需理解病灶证据在视网膜血管周围的分布及其与定量血管生物标志物的关系。本文提出一种双边空间-雅可比图像图结构,用于可解释的DR分级。每张眼底图像被表示为一个图节点,包含四条对齐的信息流:AutoMorph血管信息(X₁)、DR-XAI风格的病灶证据图(X₂)、128维基于病灶的对比学习图像嵌入(X₃),以及AutoMorph形态学生物标志物(X₄)。空间边分支(X₁₂)编码血管-病灶几何关系,雅可比分支(X₃₄)建模嵌入-生物标志物敏感性。轻量级双令牌注意力将两类边融合为最终图像图。在2,910张匹配的非增强APTOS图像上,完整模型取得0.8076准确率、0.8312二次加权卡帕系数、0.5915宏平均F1、0.9330邻近等级准确率;可转诊DR达到0.9055准确率和0.9711 AUROC。该框架定位为可解释表征学习工具,用于病灶-生物标志物假设生成,而非部署级临床分类器。代码已公开于https://github.com/Inamullah-Colab/dual-edge-dr-graph-xai。
原文摘要 · Abstract (English)
Automated diabetic retinopathy (DR) grading from colour fundus photographs can achieve strong predictive performance, but clinical interpretation requires more than an image-level label. It requires understanding how lesion evidence is distributed around retinal vessels and how this evidence relates to quantitative vascular biomarkers. We present a dual-edge spatial-Jacobian image graph for interpretable DR grading. Each fundus image is represented as a graph node with four aligned evidence streams: AutoMorph vessel information ($X_1$), DR-XAI-style lesion evidence maps ($X_2$), a 128-dimensional lesion-based contrastive image embedding ($X_3$), and AutoMorph morphometric biomarkers ($X_4$). The spatial edge branch ($X_{12}$) encodes vessel-lesion geometry, while the Jacobian branch ($X_{34}$) models embedding-biomarker sensitivity. Lightweight two-token attention fuses both edge families into a final image graph. On 2,910 matched non-augmented APTOS images, the full graph achieves 0.8076 accuracy, 0.8312 quadratic weighted kappa, 0.5915 macro-F1, and 0.9330 adjacent-grade accuracy; referable DR reaches 0.9055 accuracy and 0.9711 AUROC. The framework is positioned as an explainable representation-learning tool for lesion-biomarker hypothesis generation, rather than as a deployment-ready clinical classifier. The code is available at https://github.com/Inamullah-Colab/dual-edge-dr-graph-xai.
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