arXiv:2606.26561cs.AIcs.LG2026-06被引 19

用机器学习模型精准识别丙肝患者是否患肝硬化,准确率达96.92%

Explainable Ensemble-Based Machine Learning Models for Detecting the Presence of Cirrhosis in Hepatitis C Patients

  • 基于四种集成学习模型,筛选关键16个特征进行诊断
  • 最优模型精确率99.81%,召回率94.00%,准确率96.92%
  • 结果可解释性强,适合临床辅助决策与医学研究

丙型肝炎是由病毒引起的肝脏感染,长期可导致严重炎症及肝硬化。患者常在数十年内无明显症状,直至肝硬化进展至肝功能衰竭,可能引发脑神经损伤和消化道出血。早期发现肝硬化对预防并发症至关重要。尽管机器学习在疾病诊断中表现优异,但尚未有研究将其用于丙肝患者的肝硬化检测。本研究从加州大学欧文分校的机器学习数据仓库获取2038名埃及患者数据,包含28项属性。训练了随机森林、梯度提升机、极端梯度提升和额外树四种模型。其中额外树模型表现最佳,仅使用16个特征即达到96.92%准确率、94.00%召回率、99.81%精确率,受试者工作特征曲线下面积为96%。

原文摘要 · Abstract (English)

Hepatitis C is a liver infection caused by a virus, which results in mild to severe inflammation of the liver. Over many years, hepatitis C gradually damages the liver, often leading to permanent scarring, known as cirrhosis. Patients sometimes have moderate or no symptoms of liver illness for decades before developing cirrhosis. Cirrhosis typically worsens to the point of liver failure. Patients with cirrhosis may also experience brain and nerve system damage, as well as gastrointestinal hemorrhage. Treatment for cirrhosis focuses on preventing further progression of the disease. Detecting cirrhosis earlier is therefore crucial for avoiding complications. Machine learning (ML) has been shown to be effective at providing precise and accurate information for use in diagnosing several diseases. Despite this, no studies have so far used ML to detect cirrhosis in patients with hepatitis C. This study obtained a dataset consisting of 28 attributes of 2038 Egyptian patients from the ML Repository of the University of California at Irvine. Four ML algorithms were trained on the dataset to diagnose cirrhosis in hepatitis C patients: a Random Forest, a Gradient Boosting Machine, an Extreme Gradient Boosting, and an Extra Trees model. The Extra Trees model outperformed the other models achieving an accuracy of 96.92%, a recall of 94.00%, a precision of 99.81%, and an area under the receiver operating characteristic curve of 96% using only 16 of the 28 features.

肝硬化检测机器学习医疗诊断可解释性

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