arXiv:2606.29592cs.LGcond-mat.mtrl-sci2026-06

在电子显微镜中,感知模型比导航算法更关键,能显著提升成像效率。

STEMGym: Benchmarking Sequential Decision-Making under Dose Budgets in Autonomous Electron Microscopy

论文配图:STEMGym: Benchmarking Sequential Decision-Making under Dose Budgets in Autonomous Electron Microscopy
图 1 · 摘自论文原文
  • 用物理仿真构建15个材料场景,统一评估感知与导航的效能
  • 训练好的CNN感知模型使成像效率提升5.5倍,远超优化导航策略
  • 适合研究自主显微成像、机器学习应用在科学仪器的团队

自主科学成像的核心假设是更智能的导航(如贝叶斯或强化学习)可实现高效采样。但在扫描透射电镜(STEM)中,每次测量都会造成电子损伤。本文提出STEMGym,一个开源的Gymnasium基准,包含15个物理模拟的STEM世界,覆盖五种材料、三个难度等级和四种表征任务,以剂量-效率曲线面积(DEC-AUC)为统一指标。在33种代理配置下,真实剂量预算条件下,感知模块(分析师)是决定剂量效率的主导因素:将训练好的CNN感知模型与简单光栅扫描结合,使DEC-AUC达0.287,比无CNN的光栅基线(0.052)提升5.5倍;而用贝叶斯或自适应有限状态机导航替代光栅扫描,未带来统计显著提升。生产级视觉-语言模型在晶体缺陷分析上表现比专用CNN差约13倍。STEMGym通过在统一剂量预算下解耦感知、导航与规划,重新定义了自主电子显微镜中机器学习投入的重点,并提供了可验证的评估基础设施。

原文摘要 · Abstract (English)

A central premise of autonomous scientific imaging is that smarter navigation, whether Bayesian, RL-based, or otherwise adaptive, is the principal lever for sample-efficient acquisition. We present evidence to the contrary in scanning transmission electron microscopy (STEM), an atomic-resolution imaging modality whose every measurement deposits damaging electron dose. We introduce STEMGym, an open-source Gymnasium benchmark of 15 physics-simulated STEM worlds spanning five materials, three difficulty levels, and four characterisation tasks, scored by the Dose-Efficiency Curve area (DEC-AUC), a single scalar capturing the information-vs-dose Pareto frontier. Across 33 agent configurations under realistic dose budgets, the dominant determinant of dose efficiency is the analyst (perception) pipeline, not the navigator: pairing a trained CNN analyst with naïve raster scanning raises DEC-AUC by 5.5x over a CNN-free raster baseline (0.287 vs.\ 0.052), while substituting Bayesian or adaptive finite-state-machine navigation for raster yields no statistically significant further gain. Production-tier vision-language models further underperform task-specific CNNs by {\sim}13x on crystallographic defect analysis. By decoupling perception, navigation, and planning under a unified dose budget, STEMGym reframes where ML effort should be invested in autonomous electron microscopy and provides the measurement infrastructure to test it.

电子显微镜自主成像感知效率

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