用可解释AI识别无症状心衰早期阶段,提升诊断透明度与公平性。
Explainable Artificial Intelligence For The Detection and Characterisation of Stage B Heart Failure

- 采用SHAP、LIME等可解释技术分析心脏影像数据
- 20项研究显示现有方法缺乏对性别/种族差异的考量
- 当前评估不足,难保证临床决策的可靠与公平
Stage B心衰表现为无症状的心脏结构或功能异常,早期识别对预防进展至有症状疾病至关重要。可解释人工智能(XAI)有望支持早期检测、透明风险分层及可行动干预选择。本综述系统分析了20项应用XAI技术于Stage B心衰的研究,涵盖Web of Science、Scopus和PubMed数据库(截至2026年3月27日)。结果显示,SHAP是最常用方法,其次为LIME、显著性图和Grad-CAM;但解释性应用不一致,部分研究仅采用有限或临时的可解释手段。值得注意的是,所有研究均未比较不同性别或种族亚组的解释结果,尽管已有证据表明疾病负担存在群体差异。多数研究对XAI输出的评估不足:部分未进行验证,部分仅依赖文献对比,可能引入偏倚。这些局限表明可解释性未被系统验证或用于支持稳健、公平的临床推断。尽管XAI在提升心衰早期识别透明度方面具潜力,但当前实现仍受限于对性别与种族因素考虑不足、缺乏亚组分析、评估不一致及外部验证缺失,制约其泛化能力与临床采纳。
原文摘要 · Abstract (English)
Stage B heart failure is characterized by asymptomatic structural or functional cardiac abnormalities. Identifying individuals at this stage is clinically important, as early detection may enable targeted interventions to prevent progression to symptomatic disease. Explainable artificial intelligence (XAI) may support early detection, transparent risk stratification, and selection of clinically actionable interventions. This review examines the use of XAI in detecting and characterizing stage B heart failure. A literature search of Web of Science, Scopus, and PubMed was conducted on 27 March 2026. Studies were included if they applied AI with XAI techniques to stage B heart failure. After screening, 20 studies were included. Data on modalities, outcomes, demographic reporting, and XAI methods were extracted and synthesized. SHAP was the most commonly used method, followed by LIME, saliency maps, and Grad-CAM; however, XAI adoption was inconsistent, with some studies relying on limited or ad hoc interpretability approaches. Notably, none compared explanations across sex or ethnic subgroups, despite evidence of subgroup differences in disease burden. Evaluation of XAI outputs was often insufficient: some studies did not assess explanations, while others relied only on literature-based comparisons, introducing potential bias. These limitations suggest explainability was not systematically validated or leveraged to support robust and fair clinical inference. XAI shows promise for improving transparency in stage B heart failure identification, but current implementations remain limited. Key gaps include limited consideration of sex and ethnicity, absence of subgroup-specific analyses, inconsistent evaluation, and lack of external validation, all of which constrain generalisability and clinical adoption.
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