arXiv:2607.00431cs.LG2026-07

提出时间保真度框架TimeSynth,解决健康信号数字孪生模型失真的问题。

Timesynth: A Temporal Fidelity Framework for Health Signal Digital Twins

论文配图:Timesynth: A Temporal Fidelity Framework for Health Signal Digital Twins
图 1 · 摘自论文原文
  • 用参数化生理模型生成已知真实动态的信号,实现可控基准测试
  • 发现11种架构中相位误差达53°,相当于123毫秒,标准指标无法察觉
  • 适合关注生理信号动力学保真的医疗AI研发人员使用

健康信号数字孪生的预测模型需保持生理信号的振荡、频率、相位和状态转换动态,但现有的点对点评估指标无法检测这些关键特性的丢失。我们发现这一盲区导致模型排名错误:在11种模型架构中,点对点误差相近的模型在相位精度上相差高达53°,对应1.2赫兹心率周期约123毫秒,而标准指标无法识别。为此,我们提出TimeSynth,一个可复用的基准框架,包含基于真实脑电图、心电图和光电容积脉搏波信号拟合的生理学基础生成器,以及量化振幅、频率、相位和状态转换保真度的诊断工具。线性与全序列注意力模型虽有可接受的振幅误差,却系统性丢失频率和相位信息;具有局部时序结构的架构更佳保留动力学特性并适应可观测状态转换;然而,无一能可靠保持随机切换。由于保真度主要由架构决定,模型选择应基于具体应用场景,而非盲目寻找最优解。TimeSynth为模型接入患者数据前提供可控的预临床压力测试,具备可复用生成器与保真度诊断能力。

原文摘要 · Abstract (English)

Forecasting models for health-signal digital twins must preserve the oscillatory, frequency, phase, and state-transition dynamics of physiological signals, yet the pointwise metrics used to benchmark them cannot detect when these fundamental properties are lost. We show that this blind spot misranks models: across 11 architectures, models with comparable pointwise error diverge by up to 53° in phase accuracy, equivalent to roughly 123 ms for a 1.2 Hz cardiac rhythm and invisible to standard metrics. To enable development of models that escape such failures, we introduce TimeSynth, a controlled benchmarking framework with two reusable components: a physiologically grounded generator producing signals with analytically known ground-truth dynamics from parametric models fitted to real electroencephalography, electrocardiography and photoplethysmogram signals, along with diagnostics quantifying amplitude, frequency, phase, and state-transition fidelity. Linear and full-sequence attention models systematically lose frequency and phase information despite acceptable amplitude error, whereas architectures with localized temporal structure better preserve dynamical fidelity and adapt to observable state transitions; none, however, reliably preserves stochastic switching. Because the dominant determinant of fidelity is architectural, model choice becomes a principled, use-case-driven decision rather than a search for a single winner. TimeSynth thus supplies the controlled preclinical stress test missing before models are coupled to patient data, with a reusable generator and diagnostics for fidelity-aware development.

数字孪生生理信号时间保真度医疗AI

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