从稀疏心脏MRI重建4D全心网格,实现精准动态模拟。
Personalized 4D Whole-Heart Mesh Reconstruction from Cine MRI via Multi-Scale Temporal Modeling and Differentiable Contour Rendering

- 端到端学习图像到网格映射,结合可微轮廓渲染监督变形。
- 全心平均误差1.68±0.31mm,每帧运动抖动仅0.77±0.17mm。
- 适合心脏数字孪生与电生理仿真,支持多视角一致性建模。
从稀疏的多视图2D电影式MRI序列中准确重建4D全心网格,对构建心脏数字孪生至关重要,但受限于二维切片覆盖范围有限以及心肌形状与运动间的复杂耦合关系,仍具挑战性。现有方法通常依赖中间轮廓拟合,且多重建静态、单相或部分心脏几何结构,难以捕捉完整心腔动态。本文提出一种新颖的端到端框架,通过学习图像到网格的映射,实现全心时序网格重建。框架引入受Beer-Lambert衰减原理启发的可微轮廓渲染器,通过基于轮廓的投影损失实现对3D+t网格形变的解剖感知监督。为提升心脏周期内的时间一致性,进一步设计多尺度时间建模模块,融合全局周期级动态与局部帧间一致性,生成平滑且符合生理特征的网格轨迹。所提方法在全心平均绝对误差上达1.68±0.31 mm,运动抖动为0.77±0.17 mm/frame³,优于现有方法,同时显著提升多视角2D轮廓对齐效果,并支持下游电生理模拟的初步验证。代码将在论文接受后公开。
原文摘要 · Abstract (English)
Accurate 4D whole-heart mesh reconstruction from sparse cine MRI is critical for creating cardiac digital twins, but remains challenging due to limited 2D slice coverage and the complex coupling between cardiac shape and motion. Existing methods often rely on intermediate contour fitting and typically reconstruct static, single-phase, or partial cardiac geometries, limiting their ability to capture full-chamber dynamics. We propose a novel end-to-end framework for reconstructing temporally resolved whole-heart meshes from multi-view 2D cine MRI sequences by learning an image-to-mesh mapping. The framework incorporates a differentiable contour renderer inspired by the Beer-Lambert attenuation principle, enabling anatomy-aware supervision of 3D+t mesh deformation through contour-based projection losses. To improve temporal consistency across the cardiac cycle, we further introduce a multi-scale temporal modeling module that integrates global cycle-level dynamics with local inter-frame coherence to generate smooth and physiologically plausible mesh trajectories. The proposed method achieved a whole-heart mean absolute error of 1.68 $\pm$ 0.31 mm and a motion jitter of 0.77 $\pm$ 0.17 $\mathrm{mm}/\mathrm{frame}^{3}$, outperforming existing methods with lower reconstruction error and substantially improved motion smoothness. It also improved 2D contour alignment across multiple cine MRI views and supported downstream proof-of-concept electrophysiological simulation. The code will be released publicly upon acceptance of the manuscript for publication.
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