arXiv:2607.02051cs.CV2026-07中稿 · Medical Image Anal…

通过多原型对比学习,提升医学图像分割的精度与多样性。

Embracing Intra-Class Heterogeneity for Semi-Supervised Medical Image Segmentation: From Diversity to Precision

论文配图:Embracing Intra-Class Heterogeneity for Semi-Supervised Medical Image Segmentation: From Diversity to Precision
图 1 · 摘自论文原文
  • 生成与强度特征对齐的多个原型,捕捉同一结构内部差异。
  • 在有限标注数据下,显著优于现有方法,性能提升明显。
  • 适合处理复杂异质性医学图像,尤其适用于标注稀缺场景。

由于专家标注数据稀缺,半监督医学图像分割(SSMIS)成为有前景的方向。医学图像中许多解剖结构表现出显著的类内异质性,同一结构内不同区域呈现异质的强度模式。然而,现有方法未能充分挖掘这种由强度体现的类内异质性,导致结构表示趋同,分割精度不足。同时,标注数据稀少更难有效捕捉此类复杂异质性。为此,我们提出多原型对比学习(MPCL)框架,具备更强的多样性与更高的精度。其包含三项创新:首先,提出强度对齐的异质原型生成(IHPG),通过生成与强度特征对齐的多个原型,有效建模类内异质性;其次,通过原型空间优化(PSO)系统性地优化更具判别力和泛化能力的原型空间,增强表示多样性;最后,通过双分支知识对齐(DKA)将原型空间中的类内异质性知识高效迁移至分割网络,实现更高精度分割。在三个具有显著类内异质性的医学图像数据集上的大量实验表明,MPCL在极低标注数据条件下显著优于现有方法。

原文摘要 · Abstract (English)

Due to the scarcity of expert-annotated data, Semi-Supervised Medical Image Segmentation (SSMIS) has emerged as a promising approach. Many anatomical structures in medical images exhibit significant intra-class heterogeneity, with different regions showing heterogeneous intensity patterns within the same structure. However, existing methods inadequately exploit this intensity-manifested intra-class heterogeneity, resulting in uniform structural representations and imprecise segmentation. Furthermore, the scarcity of labeled data makes it more difficult to effectively capture such complex heterogeneity. To address this, we propose Multiple Prototype Contrastive Learning (MPCL), an SSMIS framework that possesses better diversity and better precision. It consists of three novel designs: First, we provide structural representations with better diversity and propose Intensity-aligned Heterogeneous Prototype Generation (IHPG) that effectively models intra-class heterogeneity by generating multiple prototypes aligned with intensity characteristics. Second, we further enhance more diverse structural representations and build a solid foundation for more precise segmentation through Prototypical Space Optimization (PSO) that systematically optimizes a more discriminative and generalizable prototypical space. Finally, we achieve segmentation results with better precision through Dual-branch Knowledge Alignment (DKA) that efficiently promotes intra-class heterogeneity knowledge transfer from prototypical space to the segmentation network. Extensive experiments on three medical image datasets with significant intra-class heterogeneity demonstrate that MPCL significantly outperforms existing methods, especially under extremely limited labeled data.

医学图像半监督原型学习分割精度

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