arXiv:2607.04673cs.CVcs.LG2026-07

构建可解释青光眼诊断知识图谱,让模型决策有据可查。

GlaKG: A Biomarker-Centric Fundus Knowledge Graph for Explainable Glaucoma Diagnosis and Risk Assessment

论文配图:GlaKG: A Biomarker-Centric Fundus Knowledge Graph for Explainable Glaucoma Diagnosis and Risk Assessment
图 1 · 摘自论文原文
  • 以生物标志物为中心构建眼底图像知识图谱,融合临床规则与影像特征。
  • 二分类F1达0.9953,四类风险分层准确率0.930,性能接近理论上限。
  • 每项诊断附带可追溯的推理链,适合临床验证与医生信任场景。

青光眼是全球导致不可逆失明的主要原因,但多数自动化诊断系统依赖难以解释的深度学习模型。本文提出GlaKG,一种以生物标志物为核心的视网膜图像知识图谱,整合结构化生物标志物、临床规则与图像特征,实现青光眼诊断与风险分层的可追溯推理。GlaKG包含六类实体(眼底图像、视盘、神经乳头、病灶、诊断、风险等级)、八类关系及11条临床验证规则,使每个预测均关联明确的证据链。采用后处理融合框架,将ResNet50图像嵌入与归一化知识图谱推理得分通过可调权重α结合,所有训练仅限于训练集。在公开的AI标注眼底数据集上,二分类F1为0.9953,四类风险分层准确率为0.930,加权F1为0.922;因标注高度相关于标签,故将结果视为具备清晰结构化生物标志物时的性能上限。特征重要性分析显示,知识图谱与生物标志物特征贡献相当(51.1% vs. 48.9%),推理链能识别临界病例,暴露低得分而非沉默失败。核心贡献在于提供可审计的临床推理框架,揭示每项决策背后的生物标志物证据与规则激活。

原文摘要 · Abstract (English)

Glaucoma is a leading cause of irreversible blindness worldwide, yet most automated diagnosis systems rely on opaque deep-learning models that offer little clinical interpretability. We present GlaKG, a biomarker-centric fundus knowledge graph that integrates structural biomarkers, clinically grounded rules, and image features to produce traceable reasoning for glaucoma diagnosis and risk stratification. GlaKG encodes six entity types (Fundus Image, Optic Disc, Neural Rim, Pathology, Diagnosis, Risk Level), eight relation types, and 11 clinically validated rules into a unified graph, so that every prediction is accompanied by an explicit reasoning chain linking biomarker evidence to activated clinical rules. To keep knowledge-based reasoning strictly separate from label information, we adopt a post-processing fusion framework that combines ResNet50 image embeddings with a normalized KG reasoning-chain score via a tunable weight alpha, with all fitting confined to the training split. On a publicly available, AI-annotated fundus dataset, GlaKG reaches F1 = 0.9953 for binary glaucoma classification and 0.930 accuracy with 0.922 weighted F1 for four-class risk stratification; we report openly that the dataset's biomarker annotations are highly label-correlated, and therefore frame these figures as an upper bound attainable with clean structured biomarkers rather than as leakage-free image-only performance. Feature-importance analysis shows KG-derived and biomarker features contributing near-equally (51.1% vs. 48.9%), and the reasoning chain flags borderline cases by exposing low chain scores rather than failing silently. GlaKG's central contribution is therefore a clinically auditable reasoning framework that complements raw predictive performance by explicitly exposing the biomarker evidence and rule activations behind each decision.

青光眼诊断知识图谱可解释性医学AI

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