arXiv:2607.06238cs.CV2026-07

让MRI超分辨率学会理解成像物理规律,动态优化分辨率与信噪比。

PhyMRI-SR: Toward Physics-Aware MRI Image Super-Resolution

论文配图:PhyMRI-SR: Toward Physics-Aware MRI Image Super-Resolution
图 1 · 摘自论文原文
  • 将超分辨率重构为物理感知问题,动态调整分辨率-信噪比配置。
  • 在多个数据集上超越现有方法,重建图像更真实、细节更清晰。
  • 适合医学影像研究者与临床工程师,尤其关注低资源场景应用。

磁共振成像(MRI)超分辨率对提升诊断可及性至关重要,但多数方法将其视为从固定低分辨率输入到高分辨率目标的确定性映射,忽略了成像物理的核心特性:空间分辨率与信噪比(SNR)固相关联,使得每个低分辨率扫描只是不同采集权衡下的可能实现之一。本文重新思考超分辨率为物理感知的重建问题,目标是识别最优的分辨率-SNR配置,并据此进行超分辨重建以获得高质量图像。这一设定使分辨率变为动态而非固定。为处理此类异构分辨率输入,我们通过坐标基表示,将二维高斯点阵(2D Gaussian Splatting, 2D GS)适配至MRI,实现无分辨率依赖的重建。进一步提出三项创新:(1)先验感知的高斯表示,结合解剖结构先验(用于组织特异性核初始化)和成像系统先验(通过协方差字典捕捉硬件特征);(2)物理约束信号建模方案,预测组织内在参数(质子密度ρ、有效弛豫率R2),并基于物理方程合成强度,确保对比度生物物理合理性;(3)元学习框架,通过模拟数据预训练缓解真实配对数据稀缺问题,再适应真实场景。在动态分辨率数据集与标准基准上的大量实验表明,本方法达到当前最优性能,展现出显著临床部署潜力。

原文摘要 · Abstract (English)

Magnetic resonance imaging (MRI) super-resolution is vital for improving diagnostic accessibility, yet most methods treat it as a deterministic mapping from a fixed low-resolution input to a high-resolution target. This overlooks a key property of MRI acquisition physics: spatial resolution and signal-to-noise ratio (SNR) are inherently coupled, making any given low-resolution scan merely one of many possible realizations under varying acquisition trade-offs. We rethink MRI super-resolution as a physics-aware reconstruction problem, in which the goal is to identify the optimal resolution-SNR configuration and then super-resolve it to obtain high-quality MRI results. A key implication of this formulation is that MRI resolution becomes dynamic rather than fixed. To handle such resolution-heterogeneous inputs, we adapt 2D Gaussian Splatting (2D GS) to MRI by formulating reconstruction as a coordinate-based, resolution-agnostic rendering problem. To further enhance fidelity, we introduce three innovations: (1) a prior-aware Gaussian representation that combines an Anatomical Structure Prior for tissue-specific kernel initialization with an Imaging System Prior that captures hardware characteristics via a covariance dictionary; (2) a physics-constrained signal modeling scheme that predicts intrinsic tissue parameters (proton density rho and effective relaxation rate R2) and synthesizes intensities through governing physical equations, ensuring biophysically plausible contrast; and (3) a meta-learning framework that alleviates paired-data scarcity by pretraining on simulated data and adapting to real-world conditions. Extensive experiments on dynamic-resolution datasets and standard benchmarks demonstrate that our method achieves state-of-the-art performance, highlighting its strong potential for clinical deployment.

MRI超分辨率物理建模医学影像生成模型

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