arXiv:2607.08073cs.LGeess.SP2026-07中稿 · oral presentation …

用母体胎心电图生成胎儿多普勒波形,揭示血流动力学机制。

Cross-Modal Generative Framework for Signal Translation from Fetal-Maternal Electrocardiograms to Fetal Doppler Waveforms

论文配图:Cross-Modal Generative Framework for Signal Translation from Fetal-Maternal Electrocardiograms to Fetal Doppler Waveforms
图 1 · 摘自论文原文
  • 融合母体与胎儿心电图,通过跨模态注意力生成多普勒波形。
  • 多普勒频谱均方误差降低51%,心率误差仅4.71 bpm。
  • 可分离机械性贡献成分,助力临床评估胎儿循环状态。

胎儿心电图(fECG)和多普勒超声从不同角度反映胎儿心血管功能:前者捕捉电活动,后者反映受胎盘阻力和血管顺应性影响的机械血流动力学。通过从fECG重建多普勒波形,可解析可恢复与不可恢复的多普勒成分,从而量化电活动与机械因素在胎儿循环中的相对贡献,辅助临床决策。此外,母胎心律耦合的临床证据表明母体心血管动态也会影响胎儿血流。为此,本文提出一种跨模态生成框架,结合扩张卷积与跨模态注意力,选择性融合母体心电图,并利用自注意力建模长时序依赖。模型在39例妊娠的885组同步胎儿/母体心电图与多普勒包络数据上训练,合成多普勒包络的功率谱密度均方误差(PSD MSE)为49.9 ± 15.8 dB²(比双通道基线降低51%),心率误差为4.71 ± 0.77 bpm(优于基线1.5%,相对于110–160 bpm生理范围可忽略)。跨模态注意力使PSD MSE相较简单拼接降低39%,量化了母胎耦合的贡献。该框架推进了母胎心血管系统的计算建模,实现了从双导联心电图合成多普勒波形,通过分析可恢复与残差成分,量化纯粹机械性贡献,促进更全面的胎儿评估。

原文摘要 · Abstract (English)

Fetal electrocardiogram (fECG) and Doppler ultrasound provide complementary views of fetal cardiovascular function: fECG captures electrical activity while Doppler reflects mechanical hemodynamics shaped by factors such as placental resistance and vascular compliance. Understanding the recoverable and unrecoverable Doppler components through reconstruction from fECG offers insight into the relative contributions of electrical versus mechanical factors in fetal circulation, thereby informing clinical decisions. In addition, clinical evidence of maternal-fetal cardiac coupling suggests that maternal cardiovascular dynamics may also inform fetal hemodynamics. To computationally model these relationships, we propose a cross-modal generative framework combining dilated convolutions with cross-modal attention to selectively incorporate maternal ECG and self-attention to capture long-range temporal dependencies. Trained on 885 synchronized fetal/maternal ECG and Doppler envelope segments from 39 pregnancies, our model synthesizes Doppler envelopes with power spectral density mean squared error (PSD MSE) of 49.9 +/- 15.8 dB^2 (51% lower than two-channel baseline) and heart-rate error of 4.71 +/- 0.77 bpm (1.5% better than baseline; negligible relative to the 110-160 bpm physiological range). Cross-modal attention yields a 39% PSD MSE reduction over naive dual-channel concatenation, quantifying the contribution of maternal-fetal coupling. Our proposed framework advances computational modeling of the maternal-fetal cardiovascular system by enabling the synthesis of Doppler envelopes from dual-lead ECG. By analysis of both recoverable and residual Doppler components, this approach enables quantification of the purely mechanical contributions to Doppler waveforms -- those not recoverable from electrical recordings -- ultimately facilitating a more comprehensive fetal assessment.

跨模态生成胎儿监测多普勒波形心电图

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