arXiv:2607.08299cs.LG2026-07

用分类器链推荐多联病理检验,提升准确率并解释医生决策逻辑。

MLPTR-CC: Multi-label Pathology Test Recommendation using Classifier Chains and SHAP

论文配图:MLPTR-CC: Multi-label Pathology Test Recommendation using Classifier Chains and SHAP
图 1 · 摘自论文原文
  • 构建分类器链模型捕捉检验项目间的依赖关系
  • 在常见和罕见检验上均提升F1分数,降低哈明损失
  • 结合SHAP提供症状级解释,契合临床推理

诊断决策常依赖一系列病理检验来连接患者症状与最终疾病诊断。现有临床决策支持系统多聚焦单病预测,未显式推荐中间检验组合或建模检验间依赖关系。本文将病理检验推荐问题建模为多标签分类任务,每个病例关联多个相互依赖的检验。提出基于分类器链的AI框架,采用逻辑回归、决策树、随机森林及其集成方法捕捉检验间的标签依赖。在某私立病理实验室专家标注的数据集上实验表明,分类器链模型优于独立模型,在保持高准确率的同时,提升了F1分数并降低了哈明损失,尤其对罕见检验表现更佳。为增强可信度与透明性,引入基于SHAP的可解释AI,提供症状级归因,其结果在多数情况下与既定临床推理一致。结果表明,分类器链结合SHAP为多标签病理检验推荐提供了有效且可解释的解决方案,有望在早期辅助医生选择恰当诊断检验。

原文摘要 · Abstract (English)

Diagnostic decision making often relies on a sequence of pathology tests that bridge patient symptoms and final disease diagnosis. Existing clinical decision-support systems typically focus on predicting single diseases and do not explicitly recommend sets of intermediate tests or model dependencies among them. In this paper, we formulate pathology test recommendation as a multi-label classification problem where each case is associated with multiple, interdependent tests. We propose an AI-based framework that applies classifier chains with logistic regression, decision trees, random forests, and their ensemble to capture label dependencies between tests. Experiments on an expert-curated dataset from a private pathology laboratory show that classifier-chain models outperform their independent counterparts, improving F1-score and reducing Hamming loss while maintaining high accuracy across common and rare tests. To enhance trust and transparency, we integrate SHAP-based explainable AI, providing symptom-level attributions that align with established clinical reasoning in most cases. The results demonstrate that classifier chains combined with SHAP offer an effective and interpretable approach for multi-label pathology test recommendation, with potential to support clinicians in selecting appropriate diagnostic tests at an early stage.

病理检验多标签分类可解释AI临床决策

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