提出多分辨率特征茎,解决糖尿病视网膜病变不同大小病灶的分割难题
Multi-Resolution Feature Stem for Diabetic Retinopathy lesion segmentation
- 设计多尺度输入金字塔,与UNet++并行处理不同分辨率特征
- 高分辨率提升微动脉瘤分割效果,但会降低大出血病灶性能
- 首次揭示分辨率对不同类型病灶的矛盾影响,适合医学图像分割研究者
糖尿病视网膜病变(DR)是全球可预防失明的主要原因,需借助深度学习模型实现自动病灶分割以实现早期检测与监测。然而,DR病灶尺寸差异巨大,从微小的微动脉瘤到较大的出血和渗出物不等,这种变异性对模型架构和输入分辨率提出矛盾需求,带来设计挑战。本文系统研究了输入分辨率对不同病灶类型的影响。通过在512×512和1024×1024分辨率下对比U-Net、UNet++、Vision Transformers、DeepLabV3+等多种架构的实验,发现提高输入分辨率对不同病灶具有相反影响:虽有助于细粒度微动脉瘤识别,却意外降低大出血病灶分割性能。这一反直觉现象挑战了‘更高分辨率更优’的普遍假设。为此,本文提出一种新型多分辨率特征茎(Multi-Resolution Feature Stem),作为输入级金字塔结构,与UNet++主干网络融合,实现多尺度并行处理,在保留上下文信息的同时捕捉精细细节。本工作提供了该复杂分辨率依赖行为的实证支持,并提出一种参数高效、有效缓解此权衡的实用架构。
原文摘要 · Abstract (English)
Diabetic Retinopathy (DR) is a leading cause of preventable blindness worldwide, requiring automated lesion segmentation using deep learning models for early detection and monitoring. However, DR lesions vary dramatically in size from tiny microaneurysms to large hemorrhages and exudates. This variability creates conflicting demands on the model architecture and input resolution, posing a challenge for effective design. This work investigates the impact of input resolution on different lesion types. Through systematic experimentation with multiple architectures (U-Net, UNet++, Vision Transformers, DeepLabV3+) at $512 \times 512$ and $1024 \times 1024$ resolutions, we identify a critical, counter-intuitive phenomenon where increasing input resolution has opposing effects on different lesion types. We demonstrate that while higher resolution is essential for resolving fine-grained microaneurysms, it can unexpectedly degrade performance on larger hemorrhages. This finding challenges the common assumption that higher resolution is uniformly beneficial. To address this, we propose a novel Multi-Resolution Feature Stem, an input-level pyramid integrated with a UNet++ backbone. This architecture processes multiple scales in parallel, capturing fine-grained details without sacrificing contextual information. This work contributes crucial empirical evidence of this complex, resolution-dependent behavior and a practical, parameter-efficient architecture that successfully resolves this trade-off.
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