arXiv:2607.09102eess.IVcs.AI2026-07

在缺乏医疗影像元数据时,仍能识别隐藏亚组并支持部署期分析。

Beyond Metadata: CAPRA for Hidden Subgroup Analysis under Missing Metadata in Medical Imaging

论文配图:Beyond Metadata: CAPRA for Hidden Subgroup Analysis under Missing Metadata in Medical Imaging
图 1 · 摘自论文原文
  • 通过图像语义轴预测与患者级交叉拟合校准,重建隐含亚组结构。
  • 在视网膜、皮肤和胸部X光数据中发现元数据切分遗漏的差异模式。
  • 适用于模型部署后故障分析与鲁棒学习,无需标注亚组信息。

医疗影像模型常在缺乏人口统计、采集及质量元数据的情况下部署,导致临床关键失效模式被强聚合性能掩盖,且许多鲁棒学习方法因失去组结构而失效。本文提出CAPRA,一种在缺失元数据下进行隐含亚组分析的校准代理轴框架。CAPRA通过预测图像衍生的语义轴,利用少量有标签样本的患者级交叉拟合校准轴后验,并将这些后验组织为可解释的亚组接口,支持部署时的故障分析与下游鲁棒学习,无需部署时的亚组标签。在视网膜、皮肤镜和胸部放射影像数据上,CAPRA揭示了元数据切分无法捕捉的差异模式,在数据集偏移下仍具信息量,其生成的亚组划分比仅基于图像或潜在切片的基线更贴近显式失效轴。该接口还可被下游鲁棒学习者复用,增益具有领域依赖性。总体而言,CAPRA将缺失元数据下的隐含亚组分析转化为可校准、可解释、可复用的部署接口。

原文摘要 · Abstract (English)

Medical imaging models are often deployed without the demographic, acquisition, and quality metadata needed for subgroup auditing. Once those metadata disappear, clinically critical failure modes can be masked by strong aggregate performance, and many robust-learning methods lose the group structure they rely on. We present CAPRA, a calibrated proxy-axis framework for hidden subgroup analysis under missing metadata. CAPRA predicts image-derived semantic axes, calibrates axis posteriors on a small metadata-labeled split via patient-level cross-fitting, and organizes those posteriors into a calibrated subgroup interface that supports both deployment-time failure analysis and downstream robust learning without requiring subgroup labels at deployment. Across fundus, dermoscopy, and chest radiography, CAPRA reveals disparity patterns missed by metadata-only slicing, remains informative under dataset shift, and produces subgroup partitions that align more closely with explicit failure axes than image-only or latent-slice baselines. The same interface can also be reused by downstream robust learners, although those gains are domain-dependent. Overall, CAPRA turns hidden subgroup analysis under missing metadata into a calibrated, interpretable, and reusable subgroup interface for deployment-time analysis and robust transfer.

医学影像亚组分析鲁棒学习缺失数据

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