构建了从出生到青春期的狒狒脑发育模板，支持跨年龄神经影像研究。
Longitudinal MRI template of the baboon brain from birth to adolescence
- 提出BABACOOL方法，自动生成多模态发育模板
- 基于21只狒狒4个时间点数据，覆盖出生至5岁发育期
- 可生成任意中间年龄模板，适用于猿类与人类对比研究
狒狒（Papio）是灵长类非人研究中的重要模型，属于旧世界猴，其脑容量在非人灵长类中最大之一。为促进比较发育神经科学研究，本文提出BABACOOL（BAby Brain Atlas COnstruction for Optimized Labeled segmentation）方法，用于构建多模态发育图谱，并据此生成了BaBa21——一个基于21只非洲狒狒（Papio anubis）的群体纵向发育模板。该模板包含从出生后约2周至性成熟（5年）共4个时间点的结构像（T1和T2加权）及组织概率图，为全生命周期的狒狒脑影像提供标准化参考。此外，本研究还提供全自动方法，可在任意中间年龄生成模板，支持未来特定年龄组的研究。该资源可用于狒狒脑影像的标准化，推动狒狒与人类及其他已建立发育模板的灵长类（如猕猴）之间的比较研究。
原文摘要 · Abstract (English)
The baboon (Papio) is an invaluable resource within nonhuman primate research, having the advantage of being a cercopithecoid (Old World monkey) with one of the largest brains among non-hominid primates. In order to facilitate comparative developmental neuroscience research, we present the BABACOOL (BAby Brain Atlas COnstruction for Optimized Labeled segmentation) approach for creating multi-modal developmental atlases, which we used to produce BaBa21, a population-based longitudinal developmental baboon template. BaBa21 is a spatio-temporal template that consists of structural (T1- and T2-weighted) images and tissue probability maps from a population of 21 baboons (Papio anubis) scanned at 4 timepoints beginning from about 2 weeks after birth and continuing to sexual maturity (5 years). Further, his study offers a fully automatic method for generating a template at any intermediate age for future age-specific group studies. This resource is made available to provide a normalization target for baboon data across the lifespan, including intermediate timepoints, and moreover facilitate neuroimaging research in baboons, comparative research with humans and nonhuman primate species for which developmental templates are available (e.g., macaques).
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