arXiv:2607.10093cs.CV2026-07

用一套模型同时评估胚胎分裂期的碎片、阶段和对称性,提升辅助生殖诊断精度。

EMBRACE: A Multi-task Framework for Comprehensive Quality Assessment in Cleavage-stage Embryo

  • 多任务深度学习框架,联合分割碎片、分类发育阶段、评分对称性。
  • 碎片分割Dice达0.781,阶段分类准确率99.5%,对称性评分平衡准确率90.1%。
  • 适合辅助生殖领域研究者与临床医生,助力自动化胚胎质量评估。

体外受精中分裂期胚胎评估需综合判断细胞质碎片、发育阶段和卵裂球对称性。然而传统视觉评估受观察者差异影响,尤其当碎片小、不规则或对比度低时。本研究提出EMBRACE,一种多任务深度学习框架,可从静态分裂期胚胎显微图像中联合完成细胞质碎片分割、t2/t4发育阶段分类及卵裂球对称性评分。EMBRACE采用共享的ResNet-50主干网络、基于拼接的多尺度特征融合(C-MSFF)模块、U-Net式分割解码器及两个任务专用分类头。经预设纳入与排除标准后,共9,137张标注胚胎图像被分为7,309张训练集、914张验证集和914张预留测试集。在预留测试集上,碎片分割的Dice系数为0.781,交并比为0.677;发育阶段分类准确率为0.995,宏平均F1为0.994,AUC为1.000;卵裂球对称性评分的平衡准确率为0.901,宏平均F1为0.907,二次加权卡帕系数为0.859。结果表明,将空间可解释的碎片定位与胚胎级形态评估整合于单一框架中具有可行性。临床部署前仍需外部与前瞻性验证。

原文摘要 · Abstract (English)

Cleavage-stage embryo assessment in in vitro fertilization requires the integrated interpretation of cytoplasmic fragmentation, developmental stage, and blastomere symmetry. However, conventional visual assessment is affected by observer variability, particularly when fragmented regions are small, irregular, or low contrast. This study presents EMBRACE, a multi-task deep learning framework for jointly performing cytoplasmic-fragmentation segmentation, t2/t4 developmental-stage classification, and blastomere-symmetry grading from static cleavage-stage embryo microscopy images. EMBRACE combines a shared ResNet-50 backbone, a concatenation-based multi-scale feature-fusion (C-MSFF) module, a U-Net-style segmentation decoder, and two task-specific classification heads. After predefined inclusion and exclusion criteria, 9,137 annotated embryo images were divided into 7,309 training, 914 validation, and 914 held-out test images. On the held-out test set, EMBRACE achieved a Dice coefficient of 0.781 and an intersection over union of 0.677 for fragmentation segmentation. Developmental-stage classification achieved an accuracy of 0.995, macro-F1 of 0.994, and AUC of 1.000. Blastomere-symmetry grading achieved a balanced accuracy of 0.901, macro-F1 of 0.907, and quadratic weighted kappa of 0.859. These findings support the feasibility of combining spatially inspectable fragmentation localization with embryo-level morphology assessment in a single framework. External and prospective validation is required before clinical deployment.

胚胎评估多任务学习医学影像深度学习

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