arXiv:2607.11104cs.CV2026-07

用物理守恒机制重建低计数PET,避免微弱病灶信号消失。

FlowPET: Physics-Informed Symplectic Flow Matching for Low-Count PET Reconstruction

论文配图:FlowPET: Physics-Informed Symplectic Flow Matching for Low-Count PET Reconstruction
图 1 · 摘自论文原文
  • 基于哈密顿系统构建体积守恒流,防止信号衰减。
  • 在脑部和临床数据上,比现有方法提升SSIM与PSNR,更有效恢复低对比病灶。
  • 适合高噪声医学成像重建,尤其关注微小病灶的临床研究者。

低计数正电子发射断层扫描(PET)重建受制于主流生成模型的耗散特性,其相空间收缩会导致微弱但诊断关键的病灶信号数值消失。为此,我们提出FlowPET,一种物理信息引导的框架,将重建重构为辛相空间中的体积守恒传输。通过可分离哈密顿系统参数化后验动态,该方法从构造上保证向量场无散度,理论上抵御弱信号的概率质量坍缩。为引导此保守流,我们引入基于PET算子范围-零空间分解的共轭边界条件:严格在范围空间内强制数据一致性,同时将随机不确定性注入限制在未观测的零空间。模型通过辛流匹配训练,并使用辛蛙跳积分器进行推断。在BrainWeb、临床儿科及UDPET数据集上的大量实验表明,FlowPET不仅在SSIM和PSNR上超越最先进的确定性和随机基线,更关键的是显著提升了低对比病灶的恢复能力。结果证实,施加哈密顿结构约束为高噪声场景下的医学逆问题提供了稳健的几何保护。

原文摘要 · Abstract (English)

Low-count Positron Emission Tomography (PET) reconstruction is severely hindered by the dissipative nature of prevailing generative models, where the inherent phase-space contraction leads to the numerical extinction (``wash-out'') of weak but diagnostically critical lesion signals. To overcome this geometric limitation, we propose \textbf{FlowPET}, a physics-informed framework that reformulates reconstruction as volume-preserving transport in a symplectic phase space. By parameterizing the posterior dynamics via a Separable Hamiltonian System, our approach guarantees a divergence-free vector field by construction, theoretically immunizing weak signals against probability mass collapse. To steer this conservative flow, we introduce conjugate boundary conditions based on the Range-Null space decomposition of the PET operator; this strictly enforces data consistency in the range space while confining stochastic uncertainty injection to the unobserved null space. We train the model via symplectic flow matching and perform inference using a symplectic leapfrog integrator. Extensive experiments on BrainWeb, clinical pediatric, and UDPET datasets demonstrate that \textbf{FlowPET} not only surpasses state-of-the-art deterministic and stochastic baselines in SSIM and PSNR but, more crucially, exhibits superior recovery of low-contrast lesions. The results confirm that imposing Hamiltonian structural constraints offers a robust geometric safeguard for medical inverse problems in high-noise regimes.

PET重建生成模型辛几何低剂量成像

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