arXiv:2607.11754cs.CV2026-07

解决细胞分裂导致的追踪路径混淆问题,提升显微成像追踪精度

Higher-Order Cell Tracking Transformer

论文配图:Higher-Order Cell Tracking Transformer
图 1 · 摘自论文原文
  • 以边为中心设计架构,结合3D几何先验进行注意力计算
  • 在细胞追踪挑战和细菌分裂基准上达到当前最优表现
  • 仅需400个标注即可减少59%错误,适合交互式精调场景

从活体显微成像中重建细胞谱系需要将不同时刻的细胞检测结果关联起来,包括细胞分裂的情况。现有方法通常构建候选图并关联不同帧中的细胞分割(节点)。然而,这些方法忽略了候选追踪图中的两个结构性障碍:(i) 细胞分裂会使不同的谱系路径在节点嵌入空间中纠缠;(ii) 共享同一节点的边其标签一致性接近随机,导致候选图拓扑对图神经网络的聚合无用。我们提出更高阶细胞追踪变压器(HOCT),一种以边为中心的架构,在3D几何先验下让候选细胞连接相互关注,解决了上述两个问题。在细胞追踪挑战和细菌分裂基准上的评估显示,HOCT无需深度预训练图像编码器即可达到最先进水平。此外,该方法更易微调,在人机协同设置下仅用400个标注即可快速将追踪误差降低59%,优于对比的Transformer基线模型的LoRA微调(提升6.75%)。

原文摘要 · Abstract (English)

Reconstructing lineages from live-imaging microscopy requires linking cell detections across time, including through cell divisions. A common approach is to construct a candidate graph and associate cell segmentations (nodes) across frames. However, these and other existing methods overlook two structural obstacles in candidate tracking graphs: (i) cell divisions entangle distinct lineage paths in the node embedding space, and (ii) edges sharing a node have near-random label agreement, so the candidate-graph topology carries no useful information for graph neural networks to aggregate. We propose the \textbf{Higher-Order Cell Tracking Transformer} (HOCT), an edge-centric architecture in which candidate cell links attend to one another under a 3D geometric prior, resolving both issues. Evaluated on the Cell Tracking Challenge and a bacteria division benchmark, HOCT achieves state-of-the-art results without deep pre-trained image encoders. Moreover, the proposed approach is easier to fine-tune, quickly reducing tracking errors by 59% with 400 annotations in a human-in-the-loop setting, outperforming LoRA fine-tuning of competing transformer baselines (6.75% improvement).

细胞追踪图神经网络生物图像分析

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。