arXiv:2607.16300cs.CV2026-07

联邦学习生成医疗数据,既保护隐私又保持诊断准确性。

FedDP-PALD: A Privacy-Preserving Federated Latent Diffusion Framework with Prototype Aggregation for Medical Data Synthesis

论文配图:FedDP-PALD: A Privacy-Preserving Federated Latent Diffusion Framework with Prototype Aggregation for Medical Data Synthesis
图 1 · 摘自论文原文
  • 用原型聚合与差分隐私确保训练信息不泄露。
  • 合成数据使模型性能接近真实数据,F1达0.8993。
  • 适合需跨机构协作的医疗AI研发团队使用。

医学影像与生理信号对精准诊断至关重要。构建诊断模型常需多机构患者数据,但严格隐私法规限制敏感临床记录共享。联邦学习可在不交换原始数据的前提下联合训练模型。然而现有方法存在两大问题:训练中传递的信息可能暴露某患者数据是否被使用;合成数据难以保留原始数据的预测结构,限制临床应用。为此,我们提出FedDP-PALD,一种在形式化隐私保障下用于多模态医疗数据合成的隐私保护联邦潜在扩散框架。该方法通过门控多头注意力与模态可用性掩码,联合处理胸部X光片与心电图信号,即使缺失某一模态仍具有效性。我们引入差分隐私原型混合聚合(DP-PMA),在服务器端对类别级潜在原型进行裁剪并添加校准高斯噪声后聚合,实现(ε, δ)差分隐私。在PneumoniaMNIST、ChestMNIST和MIT-BIH数据集上评估,差分隐私将摘要级攻击AUROC从0.6229±0.0026降至0.5016–0.5093(ε从1到8)。测试数据上,合成潜在空间训练获得F1分数0.8993±0.0006与AUROC 0.9057±0.0503,接近真实潜在空间训练的0.9747±0.0132。结果表明,FedDP-PALD生成的私有合成表示能有效保留决策性能,同时强抵抗成员推断攻击。

原文摘要 · Abstract (English)

Medical images and physiological signals provide valuable information for accurate diagnosis. Developing diagnostic models often requires patient data from multiple institutions, although strict privacy regulations limit the sharing of sensitive clinical records. Federated learning enables multiple hospitals to train a shared model without exchanging raw data. However, existing methods face two problems: the information exchanged during training can reveal whether a patient's data were used, and synthetic data meant to replace real records often fail to preserve their predictive structure, which limits clinical use. To address this issue, we propose FedDP-PALD, a privacy-preserving federated latent diffusion framework for multimodal medical data synthesis under formal privacy guarantees. It jointly processes chest X-ray images and electrocardiogram (ECG) signals through gated multi-head attention with modality-availability masks, remaining effective even when a modality is missing. We also introduce Differentially Private Prototype Mixture Aggregation (DP-PMA), which clips class-level latent prototypes and adds calibrated Gaussian noise before combining them on the server to maintain $(ε, δ)$ differential privacy. We evaluate FedDP-PALD on PneumoniaMNIST, ChestMNIST, and MIT-BIH datasets, where differential privacy reduced summary-level attack AUROC from 0.6229 $\pm$ 0.0026 to between 0.5016 and 0.5093 for privacy budgets from $ε= 1$ to $ε= 8$. On the test data, synthetic-latent training achieved an F1 score of 0.8993 $\pm$ 0.0006 and an AUROC of 0.9057 $\pm$ 0.0503, close to the 0.9747 $\pm$ 0.0132 real-latent training. These results show that FedDP-PALD generates private synthetic representations that preserve useful decision performance while strongly resisting membership inference.

联邦学习隐私保护医疗生成差分隐私

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