arXiv:2607.16317cs.CVcs.AI2026-07

用蒙特卡洛丢弃法评估脑瘤MRI模型置信度,自动标记不确定病例转给医生。

Monte Carlo Dropout Uncertainty and Entropy-Thresholded Selective Prediction for Architecture-Agnostic Brain Tumor MRI Triage

论文配图:Monte Carlo Dropout Uncertainty and Entropy-Thresholded Selective Prediction for Architecture-Agnostic Brain Tumor MRI Triage
图 1 · 摘自论文原文
  • 通过20次蒙特卡洛丢弃推断预测不确定性,用熵值制定拒判规则。
  • 保留最不确定的5%病例转诊后,其余准确率提升至98%,校准误差仅0.016-0.020。
  • 方法不依赖模型架构,适合临床部署,可直接用于医生辅助决策。

深度网络在脑瘤MRI分型上已达到专家水平,但临床应用仍受限于模型置信度是否可信。本文提出一种以不确定性为核心的四类脑瘤MRI(胶质瘤、脑膜瘤、垂体瘤、无肿瘤)分诊流程,通过20次蒙特卡洛丢弃计算预测熵,并据此制定明确的拒判规则。研究采用感知哈希聚类划分7,200张图像,避免近似重复数据泄露导致的精度虚高。在ViT-B/16与ResNet-50上,五次随机种子测试均显示强区分能力(宏AUC 0.994,准确率0.962和0.964),且无显著差异(p < 0.05),证明结果由不确定性管道驱动而非网络结构。单一温度标量使确定性softmax实现紧密校准(期望校准误差0.016–0.020),将最不确定的5%病例拒判后,剩余样本准确率提升至约0.98,风险-覆盖率曲线下面积为0.010–0.011。蒙特卡洛丢弃不确定性在此任务中具备校准性、非退化性,并可通过具体拒判规则直接应用,为无需依赖架构的校准式脑瘤MRI分诊提供可靠基础。

原文摘要 · Abstract (English)

Deep networks now subtype brain tumors on MRI about as well as specialist readers, yet accuracy is not what keeps them out of the clinic. What matters at the point of care is whether a model's confidence can be trusted to flag the cases it is likely to misclassify and defer them to a human. Deterministic estimates cannot: an auxiliary confidence head trained alongside the classifier collapses to a near-constant output that says nothing about correctness. This study proposes an uncertainty-first pipeline for four-class brain tumor MRI (glioma, meningioma, pituitary, no tumor) that reads predictive uncertainty from Monte Carlo (MC) Dropout over T = 20 passes and turns the resulting entropy into an explicit rule for deferring uncertain cases to a radiologist. We partitioned 7,200 images by perceptual-hash cluster, closing the near-duplicate leakage that inflates accuracy under naive splitting, and evaluated the pipeline on ViT-B/16 and ResNet-50 across five seeds along three axes: discrimination, calibration, and selective prediction. Both discriminate strongly (macro-AUC 0.994; accuracy 0.962 and 0.964), and no seed separates them (0 of 5 significant, p < 0.05), so the result is driven by the uncertainty pipeline, not the network. A single temperature scalar pulls the deterministic softmax into tight calibration (expected calibration error 0.016-0.020), and deferring the most uncertain 5% of cases lifts accuracy on the rest to about 0.98 on both (area under the risk-coverage curve 0.010-0.011). MC-Dropout uncertainty here is thus calibrated, non-collapsing, and directly actionable through a concrete deferral rule, providing an architecture-agnostic basis for calibrated, defer-to-human brain tumor MRI triage under internal validation.

脑瘤分割不确定性估计医学影像可解释性

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