arXiv:2607.17298math.NAcs.NA2026-07

对比三种重建方法在低剂量CT中的稳定性,发现TV最小化最稳健。

Stability and Robustness Analysis of Regularized Reconstruction Methods for Low-Dose Computed Tomography in Parallel-Beam Geometry

论文配图:Stability and Robustness Analysis of Regularized Reconstruction Methods for Low-Dose Computed Tomography in Parallel-Beam Geometry
图 1 · 摘自论文原文
  • 构建统一仿真框架,系统比较FBP、Tikhonov与TV的性能差异。
  • 在60投影稀疏采样下,TV方法保持最佳图像保真度与抗扰能力。
  • 提出稳定因子S,补充传统指标,揭示噪声与采样缺失下的可靠性差异。

低剂量计算机断层扫描(LDCT)虽降低辐射暴露,但因噪声和数据稀疏导致重建问题更病态。尽管正则化方法如Tikhonov和总变差(TV)能提升图像质量,其表现仍高度依赖噪声特性、采样条件及参数选择。本研究在二维平行束CT框架下,系统分析滤波反投影(FBP)、Tikhonov正则化与TV最小化的方法稳定性与鲁棒性。基于Radon变换构建统一仿真流程,采用改进的Shepp-Logan模体与临床胸腔图像,在高斯、泊松及混合噪声模型下,分别于基准(180个投影)与稀疏视图(60个投影)几何条件下评估。通过基于结构相似性(SSIM)的网格搜索优化各场景正则化参数。使用均方误差(RMSE)、峰值信噪比(PSNR)、结构相似性(SSIM)评估质量,以经验稳定因子S衡量从测量到图像空间的扰动放大程度。结果表明:FBP对噪声与欠采样极为敏感;Tikhonov正则化虽优于FBP,但对扰动仍较敏感;而TV最小化在降噪、边缘保持、精度与数值稳定性间取得最优平衡。研究揭示了LDCT中稳定-分辨率权衡,并证明所提稳定因子S为传统指标提供有效补充。

原文摘要 · Abstract (English)

Low-dose computed tomography (LDCT) reduces radiation exposure but increases the ill-posedness of the reconstruction problem due to noise and sparse data. While regularized methods like Tikhonov and Total Variation (TV) improve image quality, their performance depends heavily on noise characteristics, sampling conditions, and parameter selection. This study presents a systematic stability and robustness analysis of Filtered Back Projection (FBP), Tikhonov regularization, and TV minimization within a 2D parallel-beam CT framework. A unified simulation pipeline based on the Radon transform is developed and evaluated using both the modified Shepp-Logan phantom and a clinical thorax image. Reconstruction behavior is investigated under multiple degradation scenarios involving Gaussian, Poisson, and mixed noise models, across baseline (180 projections) and sparse-view (60 projections) acquisition geometries. To ensure a fair comparison, regularization parameters are optimized for each scenario through an exhaustive SSIM-based grid-search. Quality is assessed via RMSE, PSNR, and SSIM, while robustness is quantified through an empirical Stability Factor S measuring perturbation amplification from measurement to image space. The results show that FBP is highly sensitive to noise and undersampling. Tikhonov regularization improves structural fidelity compared with FBP but remains more sensitive to perturbation than TV. Conversely, TV provides the best compromise between noise suppression, edge preservation, accuracy, and numerical stability. These findings highlight the stability-resolution trade-off in LDCT and demonstrate that the proposed Stability Factor S offers valuable complementary information to conventional metrics.

医学成像正则化稳定性分析

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