用标注的病灶图训练模型,推理时无需面具也能精准分类皮肤病变。
Privileged Lesion-Context Relational Distillation for Mask-Free Skin Lesion Classification

- 训练时利用病灶掩码学习病灶与上下文关系,推理时仅需原图
- 在HAM10000上达到0.773的宏平均F1,ISIC 2018上达0.732
- 适合临床部署,无需额外分割模型,结果可解释性强
准确的皮肤病变分类依赖于病灶分割掩码,但推理时需要掩码或额外分割模型会降低临床实用性并增加计算开销。本文提出特权病灶-上下文关系蒸馏(PLCRD),一种教师-学生框架,在训练阶段利用掩码,推理阶段仅需图像。教师联合分析原始皮肤镜图像及其掩码引导的病灶区域,学习病灶特异性和上下文诊断表征。学生通过互补知识迁移机制,传递教师的诊断分布、病灶关注注意力、病灶间关系几何结构及病灶-上下文结构。PLCRD将深层表征分解为病灶和上下文嵌入,并通过病灶间相似性对齐、病灶-上下文亲和力匹配、分离正则化与类别感知关系学习来传输其关系结构。该方法避免了异构教师-学生架构间的直接特征匹配,使学生在不访问掩码的情况下内化掩码指导的诊断结构。在HAM10000上采用病灶不重叠数据划分评估,外部验证于ISIC 2018且未重新训练。PLCRD在HAM10000上获得0.773±0.018的病灶级宏平均F1、0.764±0.023的平衡准确率和0.976±0.002的宏平均AUROC;在ISIC 2018上获得0.732±0.008的宏平均F1。结果表明,特权病灶标注可转化为可迁移的关系知识,实现实用且可解释的无掩码皮肤病变分类。
原文摘要 · Abstract (English)
Accurate skin lesion classification can benefit from lesion segmentation masks, but requiring masks or an auxiliary segmentation model during inference reduces clinical practicality and increases computational complexity. This work introduces Privileged Lesion-Context Relational Distillation (PLCRD), a teacher-student framework that exploits lesion masks exclusively during training while preserving image-only inference. The privileged teacher jointly analyzes the original dermoscopic image and its mask-guided lesion region to learn lesion-specific and contextual diagnostic representations. An image-only student is then trained through complementary knowledge-transfer mechanisms that convey the teacher's diagnostic distribution, lesion-focused attention, inter-lesion relational geometry, and lesion-context structure. PLCRD decomposes deep representations into lesion and contextual embeddings and transfers their relational organization through inter-lesion similarity alignment, lesion-context affinity matching, separation regularization, and class-aware relational learning. This formulation avoids direct feature matching between heterogeneous teacher and student architectures and enables the student to internalize mask-informed diagnostic structure without accessing masks at deployment. The framework was evaluated on HAM10000 using lesion-disjoint data partitioning and externally validated on ISIC 2018 without retraining. PLCRD achieved a lesion-level macro-F1 of 0.773 +/- 0.018, balanced accuracy of 0.764 +/- 0.023, and macro-AUROC of 0.976 +/- 0.002 on HAM10000, together with a macro-F1 of 0.732 +/- 0.008 on ISIC 2018. The results indicate that privileged lesion annotations can be transformed into transferable relational knowledge, yielding a practical and interpretable approach to mask-free skin lesion classification.
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