冻结生理编码器,仅更新治疗模块,实现可审计的医疗干预预测模型更新。
Drift-Adaptive ICU Intervention Prediction: Freezing the Physiological Encoder for Auditable Model Updating

- 分离生理与治疗特征,仅更新治疗流和融合头,保持生理编码器不变。
- 在三阶段时间划分数据上,平均AUROC达0.9316,稳定性提升六倍。
- 支持逐实例溯源与可解释性检索,适合需要合规审计的临床部署场景。
临床决策支持系统随治疗规范演进而性能下降,但模型更新不仅面临准确率挑战,更受治理约束:一旦重新训练触及所有参数,便无法追溯更新来源。本文提出双流架构,将生理(LSTM)与治疗(MLP)表征分离。在分布变化与准确率双重触发下,仅更新治疗流与融合头,保持生理编码器比特级与源模型一致。审计日志记录更新依赖的治疗特征,证据检索通过PubMed查询关联每例的冻结编码器。在84,792条MIMIC-IV住院记录、按三年时期划分的数据上评估,该约束策略近乎无代价:整体判别能力接近全量更新(平均AUROC 0.9316 vs. 0.9249),在血管活性药物预测上更优,气管插管略逊;跨种子稳定性提升六倍。顺序应用于四次时期过渡时,检测器成功定位2020年边界,且仅基于分布变化触发。将更新限制在指定模块,既保持判别力又从结构上约束更新范围。属性条件检索在冻结状态下对源模型追踪更紧密(生理Jaccard 0.593 vs. 0.536),但不完全复制,此优势源于冻结流的结构性保证——权重不变不等于归因不变,该设计使前者可保证,后者可观测。
原文摘要 · Abstract (English)
Clinical decision support degrades as treatment protocols evolve, but the obstacle to updating a deployed model is governance as much as accuracy: once retraining touches every parameter, no one can say afterwards where the update acted. We propose a two-stream architecture separating physiological (LSTM) from treatment (MLP) representations. On a dual distributional and accuracy trigger, updates are confined to the treatment stream and fusion head, leaving the physiological encoder bitwise identical to the source model. Audit logs record which treatment features the update relied on, and evidence retrieval couples per-instance PubMed queries to the frozen encoder. We evaluate on 84,792 MIMIC-IV stays split by three-year era. The constraint proved close to free: selective adaptation cost nothing in aggregate discrimination against unconstrained full adaptation (mean AUROC 0.9316 vs. 0.9249; ahead on vasopressor, marginally behind on intubation) while being six-fold more stable across adaptation seeds. Run sequentially over four era transitions, the detector located the 2020 boundary rather than assuming it, firing once and on the distributional leg alone. Confining updates to named architectural blocks therefore costs little discrimination and bounds each update's scope by construction rather than by inference after the fact. Attribution-conditioned retrieval tracked the source model more closely under the freeze than under full adaptation (physiology Jaccard 0.593 vs. 0.536) without reproducing it, an advantage specific to the frozen stream: a guarantee over weights is not a guarantee over attributions, and this design makes the former structural while leaving the latter observable.
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