用神经网络实现胎儿脑部多回波MRI的高分辨率重建,支持定量T2成像。
PRIME-SVR: Physics-infoRmed Implicit Multi-Echo Slice-to-Volume Reconstruction for Fetal T2 mapping

- 用两个神经网络联合建模空间信号与采集退化,实现多回波连续重建。
- 在0.55特斯拉下首次生成0.8毫米各向同性T2图,精度提升30%以上。
- 自监督训练,可减少扫描时间至5分钟,适合临床快速定量成像。
切片到体积分割(SVR)是获取高分辨率3D胎儿脑影像的标准方法,但现有方法仅针对临床回波时间(TE)优化,无法用于非临床TE下的定量T2映射。本文提出PRIME-SVR,首个基于隐式神经表示(INR)的多回波联合高分辨率重建框架。一个全连接网络建模空间坐标到多回波信号强度的连续函数,另一网络估计每切片的采集退化。通过基于玻尔兹曼方程的正则化强制跨回波一致性,适应性加权增强退化数据的耦合。方法完全自监督。在39例体内胎儿数据(13名受试者×3个TE,双中心、双厂商、1.5T和0.55T场强)上验证,相比现有最优方法,重建锐度提升47%,解剖准确率提高30%,跨回波结构一致性提升14%。首次实现0.55T下0.8mm各向同性T2图,且首例基于INR的SVR T2图。同时显著加速定量成像:多回波采集从15分钟减至10分钟,白质与深灰质T2误差<1.7%;高质量扫描可压缩至5分钟,平均误差2.3%。
原文摘要 · Abstract (English)
Slice-to-volume reconstruction (SVR) is the standard method for obtaining high-resolution (HR) 3D fetal brain volumes from motion-corrupted 2D MRI slice stacks acquired in multiple orientations. Existing SVR methods are optimized and validated only for clinical-range echo times (TEs), limiting their use at non-clinical TEs and making them incompatible with quantitative T2 mapping, a protocol- and center-independent biomarker of fetal brain maturation requiring HR reconstructions across multiple TEs. We present PRIME-SVR, the first implicit neural representation (INR) framework for joint HR reconstruction from multi-echo MRI. A single fully connected network models a continuous function from spatial coordinates to signal intensities across TEs, while a second network estimates slice-specific acquisition degradations. Cross-TE coherence is enforced via a Bloch equation-derived regularization penalizing deviations from expected T2 decay, with adaptive weighting that strengthens coupling for degraded stacks. The method is fully self-supervised. We validate PRIME-SVR on 39 in vivo fetal acquisitions (13 subjects x 3 TEs) from two centers, two vendors, and two field strengths (1.5 T and 0.55 T). Compared to state-of-the-art SVR, PRIME-SVR improves reconstruction sharpness by 47%, anatomical accuracy by 30%, and cross-TE structural consistency by 14%. It enables reconstruction at late TEs previously inaccessible to SVR, yielding the first 0.8 mm isotropic T2 maps at 0.55 T and the first T2 maps derived from INR-based SVR. PRIME-SVR also accelerates quantitative imaging by reducing the data needed for multi-TE reconstruction, cutting acquisition from 15 to 10 minutes while keeping T2 accuracy within 1.7% in white and deep gray matter, or to 5 minutes with a mean T2 error of 2.3% for high-quality acquisitions.
Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。