提出新方法提升多模态大模型量化精度，避免关键通道失真。

Multimodal large language models (MLLMs) require huge memory and computational costs, which limits their practical deployment. Post-training quantization (PTQ) techniques offer an efficient solution for model compression and inference acceleration. Yet, the quantized model faces performance degradation due to outlier channels, which are highly sensitive to quantization and substantially impair activation fidelity and task accuracy. To protect these salient channels during quantization, existing PTQ methods leverage modality- or token-level metrics to guide channel-wise scaling (CWS) of LLM decoders. However, these orthogonal measurements fail to capture channel-wise impacts on task-specific loss, and the misalignment between importance and scaling factors ultimately leads to suboptimal performance. To address this issue, we propose C-PTQ, a unified channel-wise PTQ method that harmonizes task-specific loss perturbation and quantization error. Motivated by second-order derivatives, we design a Fisher-weighted objective as a tractable Hessian approximation, seamlessly injecting task sensitivity into the scaling process. Notably, we achieve state-of-the-art performance without auxiliary modules like LoRA, thereby maintaining high efficiency. Experiments on Qwen2.5VL, InternVL2 and LLaVA-OV across 8 benchmarks demonstrate our effectiveness in both weight-only and weight-activation settings.