用虚拟数据对齐特征,实现少标注下的睡眠内镜气道精准分割。
ASTRA-Net: Anatomy-Specific Transfer and Representation Alignment for Drug-Induced Sleep Endoscopy Segmentation

- 利用虚拟内镜图像对齐特征,提升真实数据稀缺时的分割能力。
- 在100帧测试集上达0.8927平均Dice,0.8239 mIoU,表现稳定可靠。
- 适合临床急需量化分析但标注成本高的睡眠呼吸障碍研究场景。
定量药物诱导睡眠内镜(DISE)需要在特定解剖层面准确界定气道边界。像素级标注稀缺,人工勾画难以规模化。为此,本文提出ASTRA-Net,在有限真实标注下实现已知平面的DISE分割。第一阶段通过14,250张由CT生成的虚拟内镜图像与真实帧,对齐ConvNeXt-Base的中间特征表示;虚拟图像仅用于特征对齐。第二阶段在401张真实标注帧上微调四个独立的UNet++解码器,并引入结构化零掩码监督,约束不兼容平面输出和无效帧。采用最大均值差异(MMD)、域对抗学习或两者结合的六种对齐配置。在100帧的预留测试集上,五模型MMD-only集成达到0.8927的平均Dice系数,95%置信区间为0.8631至0.9160,平均交并比为0.8239。同一配置的分类增强变体在相同测试集上实现四平面顶级分类准确率0.92。结果表明,当真实标注有限时,ASTRA-Net可支持帧级、平面特异的气道边界识别。
原文摘要 · Abstract (English)
Quantitative drug-induced sleep endoscopy (DISE) requires reliable airway boundaries at specific anatomical levels. Pixel-level DISE annotations are scarce, and manual contouring limits the scalability of quantitative assessment. To address this limitation, we developed ASTRA-Net for known-plane DISE segmentation with limited real annotations. Stage 1 aligned intermediate ConvNeXt-Base representations from 14,250 unlabeled virtual endoscopy frames derived from computed tomography and real DISE frames. Virtual images were used only for feature alignment. Stage 2 fine-tuned four independent UNet++ decoders on 401 real annotated frames. Structured zero-mask supervision constrained incompatible plane outputs and invalid frames. Six alignment configurations used maximum mean discrepancy, domain adversarial learning, or both objectives. On a hold-out evaluation set of 100 frames, the five-model MMD-only segmentation ensemble achieved a mean Dice of 0.8927, with a 95% image-level bootstrap interval of 0.8631 to 0.9160. The mean intersection over union was 0.8239. A classification- enabled variant of the same alignment configuration reached a restricted four-plane top-1 accuracy of 0.92 on the same hold-out frames. These results indicate that ASTRA-Net can support frame-level, plane-specific DISE boundary delineation when real annotations are limited.
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