arXiv:2607.24441eess.IVq-bio.QM2026-07

用模型重建法快速精准测化学成分分布,还纠正磁场不均问题。

Rapid quantitative chemical composition mapping using model-based MRI reconstruction with field inhomogeneity correction

  • 把化学成分先验知识嵌入模型,不用拍高分辨谱就可算出浓度图。
  • 20秒扫描误差仅0.01 mol/mol,精度0.09 mol/mol,适合动态过程监测。
  • 支持稀疏采样,5秒成像性能几乎不变,适合工业实时检测。

磁共振波谱成像在化工应用中极具吸引力,尤其适用于需要快速评估空间化学组成变化的反应监测。传统方法如化学位移成像引入额外的光谱编码维度,显著增加采集时间。为此,本文提出一种基于模型的重建框架,将化学组分的先验光谱知识嵌入正向模型,加速成分图生成,无需获取高分辨率光谱即可重建各组分摩尔比图。该方法进一步考虑主磁场不均匀性,尤其适用于大孔径系统(如过程工程场景)。2D多梯度回波幻影实验表明,该方法可准确测定单峰与多重峰组分的摩尔比。20秒扫描下,偏差约为0.01 mol/mol,精度为0.09 mol/mol,满足动态过程监测需求。通过稀疏k空间采样,可将扫描时间进一步缩短至5秒,定量性能仅有轻微下降。

原文摘要 · Abstract (English)

Magnetic resonance spectroscopic imaging methods are particularly attractive for chemical engineering applications, including the monitoring of chemical reactions, where a rapid assessment of spatial variations in chemical composition is required. Conventional approaches, such as chemical shift imaging, introduce an additional spectral-encoding dimension, which substantially increases acquisition time. Consequently, fast spatially resolved spectroscopy remains an active research topic. This work uses a model-based reconstruction framework that embeds a priori spectral knowledge of the involved chemical components into the forward model to accelerate composition mapping. It allows for the reconstruction of molar ratio maps for individual chemical components without acquiring high-resolution spectra. Extending from previous studies, the proposed model accounts for inhomogeneities of the main field, which become more pronounced in systems with larger bores relevant for process engineering. Phantom experiments employing a 2D multi-gradient echo sequence demonstrate the ability to determine molar ratios for chemical components with single peaks as well as multiple peaks in their spectra. The bias and precision of the method remain around 0.01 mol/mol and 0.09 mol/mol, respectively, for a 20 s scan, indicating suitability for dynamic processes. Finally, acquisition time can be reduced further by applying sparse k-space sampling, potentially shortening the scan to 5 s with only minor degradation in quantitative performance.

MRI重建化学成像快速扫描磁场校正

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