arXiv:2607.28687cs.LGcs.AI2026-07

AI融合多模态技术,提升老年人认知障碍早期检测与管理精度。

Technological Advances in Detecting and Managing Cognitive Impairment in Older Adults: Trends, Challenges, and Future Directions

  • 用AI分析脑电、影像、血液和数字信号,实现多源数据融合检测。
  • 血浆p-tau217已具备临床价值,2025年首款阿尔茨海默病血液检测获批。
  • 适合医疗研发、老年健康管理和人工智能交叉领域研究者参考。

随着人口老龄化,从轻度认知障碍(MCI)发展为痴呆是未来几十年的主要健康挑战,但常规评估常错过早期迹象。本文系统综述了针对老年人认知障碍检测与管理的技术进展,涵盖神经生理信号(主要为脑电图,EEG)、结构与分子神经影像(MRI及淀粉样蛋白/tau PET)、血液生物标志物和数字标记,并通过人工智能(AI)、机器学习(ML)与深度学习(DL)进行整合。文章提出跨学科分类体系、强调个体与站点独立验证的方法学严谨性视角、分层筛查至干预的集成早期检测框架,以及检测方法、干预措施和风险/保护因素的对比表格。脑电标记(α/θ变化、P300潜伏期)与深度模型(CNN、LSTM/BiLSTM、Transformer、自监督脑电基础模型)表现出高准确率,但多数基于小规模单中心数据集,难以通过严格外部验证。其他方面进展显著:血浆p-tau217已具临床实用性,首个血液检测将于2025年获批辅助阿尔茨海默病诊断;抗淀粉样蛋白疗法(lecanemab、donanemab)虽获批准但疗效有限且存争议;多领域生活方式预防策略趋于成熟。可穿戴设备、远程监测、语音与虚拟现实工具实现连续、生态有效的追踪,多模态融合提升敏感性与特异性。现存障碍包括标准化、可解释性、数据隐私及公平、经外部验证的部署。该领域的近期潜力在于可信赖、多模态、纵向验证系统,将早期发现与可行动的个性化护理相连接。

原文摘要 · Abstract (English)

As populations age, cognitive decline from mild cognitive impairment (MCI) to dementia is a defining health challenge of the coming decades, yet routine assessment often misses its earliest signs. This article critically synthesizes recent technological advances for detecting and managing cognitive impairment in older adults, spanning neurophysiological signals (chiefly electroencephalography, EEG), structural and molecular neuroimaging (MRI and amyloid/tau PET), blood-based biomarkers, and digital markers, integrated through artificial intelligence (AI), machine learning (ML), and deep learning (DL). Beyond summarizing, it contributes a cross-disciplinary taxonomy, a methodological-rigor lens foregrounding subject- and site-independent validation, an integrative early-detection framework linking tiered screening to intervention, and comparison tables of detection methods, interventions, and risk and protective factors. EEG markers (alpha/theta changes, P300 latency) and deep models (CNNs, LSTM/BiLSTM, transformers, self-supervised EEG foundation models) report strong accuracy, yet many rest on small, single-site datasets unlikely to survive rigorous external validation. Elsewhere, gains are tangible: plasma p-tau217 has reached clinical utility, with the first blood test cleared to aid Alzheimer's diagnosis in 2025; anti-amyloid therapies (lecanemab, donanemab) are approved despite modest, contested benefits; and multidomain lifestyle prevention has matured. Wearable, remote, speech, and virtual-reality tools enable continuous, ecologically valid monitoring, and multimodal fusion improves sensitivity and specificity. Barriers remain: standardization, explainability, data privacy, and equitable, externally validated deployment. The field's near-term promise lies in trustworthy, multimodal, longitudinally validated systems linking early detection to actionable, personalized care.

认知障碍AI医疗多模态融合老年健康

Thank you to arXiv for use of its open access interoperability. PaperDance 不是 arXiv 官方产品;中文卡片由大模型生成,请以原文为准。