arXiv:2607.29182eess.IVcs.LG2026-07

用少量数据快速校正脑部超声聚焦的相位幅度偏差,提升治疗精度与效率。

Few-shot Deep Learning for Phase-Amplitude Aberration Correction in Transcranial Focused Ultrasound

论文配图:Few-shot Deep Learning for Phase-Amplitude Aberration Correction in Transcranial Focused Ultrasound
图 1 · 摘自论文原文
  • 基于患者CT图像,用少量样本训练深度模型预测超声阵列各单元的校正参数。
  • 在12例颅骨上实现平均相位误差0.155弧度、焦点偏移仅0.467毫米。
  • 无需全波仿真,速度比传统方法快2535倍,适合临床实时应用。

经颅聚焦超声(tFUS)是一种非侵入性神经调控与治疗技术,但颅骨结构不均导致复杂的患者特异性相位与幅度畸变,使声焦点偏移目标,影响疗效与安全。传统时反演(TR)仿真虽可校正,却依赖高耗时的全波求解器,难以用于实时和迭代治疗规划。本文提出一种少样本深度代理框架,仅需10个靶点即可从患者CT图像中快速预测96元三维相控阵的各单元相位与幅度校正。模型采用几何感知编码器提取共享颅骨路径特征,分叉处理相位分类与幅度回归,其中相位周期性通过圆期望解码处理。模型在多样化颅骨数据上预训练后,可在未见患者上快速微调。在12例颅骨的留一交叉验证中,平均相位CMAE为0.155弧度,幅度rMAE为9.089%,焦点中心误差0.467毫米,Dice分数94.422%,峰值压力比92.332%,相较TR仿真提速约2535倍。代码已开源。

原文摘要 · Abstract (English)

Transcranial focused ultrasound (tFUS) is a non-invasive technique that delivers focused acoustic energy through the skull for neuromodulation and therapeutic applications. However, the heterogeneous structure of the skull induces complex, patient-specific phase and amplitude aberrations that distort the acoustic focus and deviate it from the intended target, compromising therapeutic efficacy and safety. Conventional time-reversal (TR) simulations can correct these aberrations but rely on computationally expensive full-wave solvers, making them impractical for real-time use and iterative treatment planning. We propose a few-shot deep surrogate framework that predicts per-element phase and amplitude corrections for a 96-element 3D phased-array transducer from patient CT images. A geometry-aware encoder extracts skull-path features shared across dedicated phase classification and amplitude regression branches, where phase periodicity is handled via circular expectation decoding. The framework is pretrained on diverse skull geometries and fine-tuned with only ten target points, enabling rapid adaptation to unseen patients without full patient-specific simulation. Evaluated via leave-one-out cross-validation across 12 skulls, it achieves a mean phase CMAE of 0.155 rad and amplitude rMAE of 9.089%, a focal centroid error of 0.467 mm, Dice score of 94.422%, and peak pressure ratio of 92.332%, with an approximately 2,535 times speedup over TR simulation. The code is available at https://github.com/Minju-Seol/fewshot-tfus-correction.

超声治疗少样本学习深度代理医学影像

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